Publications by authors named "Natisha R Field"
Article Synopsis
- Genetic mutations and epigenetic changes work together to promote cancer by impacting cancer-related genes, particularly the SWI/SNF complex members SMARCA4 and SMARCA2.
- The simultaneous loss of both SMARCA4 and SMARCA2 is notably lethal and is a distinctive characteristic in specific cancers like early-onset ovarian cancer and other rare tumors.
- The review explores the common clinical and molecular traits of cancers with this dual loss, the mechanisms leading to their dysfunction, and potential targeted therapies for these conditions.*
SWI/SNF (SWItch/Sucrose Non-Fermentable) is the most frequently mutated chromatin-remodelling complex in human malignancy, with over 20% of tumours having a mutation in a SWI/SNF complex member. Mutations in specific SWI/SNF complex members are characteristic of rare chemoresistant ovarian cancer histopathological subtypes. Somatic mutations in , encoding one of the mutually exclusive DNA-binding subunits of SWI/SNF, occur in 42-67% of ovarian clear cell carcinomas (OCCC).
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