Publications by authors named "Nati Malachi"
Article Synopsis
- Delivering large therapeutic proteins effectively across biological barriers like the blood-brain barrier is challenging, but Toxoplasma gondii, a parasite, shows promise in overcoming this issue by naturally moving from the gut to the central nervous system.
- Researchers have engineered T. gondii's secretion systems to facilitate the delivery of these proteins into neurons, testing their effectiveness in lab cultures, brain organoids, and living mice.
- The study specifically highlights the successful delivery of the MeCP2 protein, which could be a potential treatment for Rett syndrome, while also discussing the system's limitations and potential for future improvements.
Metazoan core promoters, which direct the initiation of transcription by RNA polymerase II (Pol II), may contain short sequence motifs termed core promoter elements/motifs (e.g. the TATA box, initiator (Inr) and downstream core promoter element (DPE)), which recruit Pol II via the general transcription machinery.
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