Publications by authors named "Nathiya D"

The tumor microenvironment (TME) has drawn much interest recently in the search for innovative cancer therapeutics, especially in light of the growing body of evidence supporting the efficacy of immune checkpoint inhibitors (ICIs). The TME comprises various cell types within the extracellular matrix (ECM), such as immune cells, endothelial cells, and cancer-associated fibroblasts (CAFs). Throughout the malignancy, these cells interact with cancerous cells and with one another.

View Article and Find Full Text PDF

Gynecologic cancer, a prevalent and debilitating disease affecting women worldwide, is characterized by the uncontrolled proliferation of cells in the reproductive organs. The complex etiology of gynecologic cancer encompasses multiple subtypes, including cervical, ovarian, uterine, vaginal, and vulvar cancers. Despite optimal treatment strategies, which typically involve cytoreductive surgery and platinum-based chemotherapy, gynecologic cancer frequently exhibits recalcitrant relapse and poor prognosis.

View Article and Find Full Text PDF

Glutaminyl-peptide cyclotransferase-like protein (QPCTL) is a newly discovered enzyme that has sparked interest owing to its possible role in cancer genesis and progression. Initially discovered as a post-translational modification regulator of protein maturation, QPCTL has emerged as a key participant in cancer biology. Recent research has linked QPCTL to numerous essential cancer-related processes, including cell proliferation, migration, invasion, and apoptosis.

View Article and Find Full Text PDF

Background: Vitamin D, essential hormone for endocrine, autocrine, and paracrine functions. A billion people are deficient globally which contributing to numerous health issues. This study explores the link between vitamin D levels and sleep quality, impacting mental and physical health in adults.

View Article and Find Full Text PDF
Article Synopsis
  • West Nile Virus (WNV) poses a significant global health risk, expanding into new regions due to climate change enhancing mosquito activity, leading to year-round virus transmission.
  • Recent advancements in genomic technologies have improved understanding of WNV's behavior and potential treatment options, yet the lack of an approved vaccine means management relies heavily on supportive care for severe cases.
  • There is a pressing need for innovative vector control methods and adaptive public health strategies that integrate research, policy, and community efforts to effectively combat WNV's evolving challenges.
View Article and Find Full Text PDF

The menstrual cycle is an intricate biological process governed by hormonal changes that affect different facets of a woman's reproductive system. This review provides an overview of neurotransmitter alterations during different menstrual cycle phases and their effects on physiology and psychology. During the follicular phase, rising estrogen levels increase serotonin synthesis, enhancing mood, cognition, and pain tolerance.

View Article and Find Full Text PDF

Alzheimer's disease (AD) is a leading cause of cognitive decline in the aging population, presenting a critical need for early diagnosis and effective prognostic tools. Epigenetic modifications, including DNA methylation, histone modifications, and non-coding RNAs, have emerged as promising biomarkers for AD due to their roles in regulating gene expression and potential for reversibility. This review examines the current landscape of epigenetic biomarkers in AD, emphasizing their diagnostic and prognostic relevance.

View Article and Find Full Text PDF

Dengue fever, caused by the dengue virus and transmitted through Aedes mosquitoes, is a growing public health concern, particularly in tropical and subtropical regions. Traditionally associated with febrile and hemorrhagic symptoms, recent research suggests a potential link between dengue and cognitive impairments. This systematic review assessed existing research to understand the association between dengue virus infection and cognitive impairments, including dementia, Alzheimer disease, memory loss, and confusion.

View Article and Find Full Text PDF

The recent global resurgence of Mpox (formerly monkeypox), primarily transmitted via close contact and respiratory droplets, highlights a significant shift in its epidemiology, particularly among men who have sex with men (MSM). This resurgence underscores the need for robust public health responses and improved surveillance. This comprehensive review of current literature focuses on recent outbreaks, virology, and available treatments.

View Article and Find Full Text PDF

The development of cancer immunology heavily relies on the interaction between long non-coding RNAs (lncRNAs) and molecular chaperones. By participating in gene regulation, lncRNAs interact with molecular chaperones, which play a critical role in protein folding and stress responses, to influence oncogenic pathways. This interaction has an impact on both the immune cells within the tumor microenvironment and the tumor cells themselves.

View Article and Find Full Text PDF
Article Synopsis
  • Metabolic dysfunction-associated fatty liver disease (MAFLD) involves fat accumulation in the liver and can progress to severe stages like steatohepatitis and fibrosis, influenced by both environmental and genetic factors.
  • Long non-coding RNAs (lncRNAs) are RNA molecules that regulate gene expression and have been linked to various liver diseases, including MAFLD, although their specific roles in this condition remain largely unclear.
  • This review highlights recent findings on lncRNAs in MAFLD's development and explores their potential as therapeutic targets for managing this prevalent liver disease.
View Article and Find Full Text PDF
Article Synopsis
  • * The text discusses key psychedelic substances (e.g., psilocybin, MDMA, LSD) and their therapeutic potential, mechanisms, and the current regulatory landscape involving their legal status, particularly their classification as Schedule I substances.
  • * Regulatory bodies like the FDA and EMA are monitoring psychedelic development closely, emphasizing the need for careful regulation to ensure safety, efficacy, and the therapeutic benefits of these drugs.
View Article and Find Full Text PDF

The integration of artificial intelligence (AI) into the diagnosis and treatment of autism spectrum disorder (ASD) represents a promising frontier in healthcare. This review explores the current landscape and future prospects of AI technologies in ASD diagnostics and interventions. AI enables early detection and personalized assessment of ASD through the analysis of diverse data sources such as behavioural patterns, neuroimaging, genetics, and electronic health records.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates how urban and rural living affects the health-related quality of life (HR-QoL) of patients with Graves' disease in Rajasthan, India, focusing on differences in demographics and health factors.
  • It analyzed 107 patients, finding that urban individuals generally had better HR-QoL scores compared to their rural counterparts, with notable differences in gender ratio, BMI, and lifestyle habits.
  • The research highlights that rural patients experience worse physical and mental health outcomes, emphasizing the need for improved healthcare resources and awareness in rural regions.
View Article and Find Full Text PDF

Cancer ranks among the most life-threatening diseases worldwide and is continuously affecting all age groups. Consequently, many research studies are being carried out to develop new cancer treatments, but many of them experience resistance and cause severe toxicity to the patients. Therefore, there is a continuous need to design novel anticancer agents that are target-based, have a higher potency, and have minimal toxicity.

View Article and Find Full Text PDF

Asthma is a chronic inflammatory condition that affects the airways, posing a substantial health threat to a large number of people worldwide. Bronchodilators effectively alleviate symptoms of airway obstruction by inducing relaxation of the smooth muscles in the airways, thereby reducing breathlessness and enhancing overall quality of life. The drug targeting to lungs poses significant challenges; however, this issue can be resolved by employing nano- and micro-particles drug delivery systems.

View Article and Find Full Text PDF

The present study investigated the relationship between MSH3 and MSH6 genes in lung cancer patients. Genotyping of lung cancer patients and healthy controls was performed. Odds ratio values were calculated and survival analysis performed.

View Article and Find Full Text PDF

Objective: This study aimed to investigate the burden of the COVID-19 pandemic on tuberculosis (TB) trends, patient demographics, disease types and hospitalisation duration within the Respiratory Medicine Department over three distinct phases: pre-COVID-19, COVID-19 and post-COVID-19.

Design: Retrospective analysis using electronic medical records of patients with TB admitted between June 2018 and June 2023 was done to explore the impact of COVID-19 on patients with TB. The study employed a meticulous segmentation into pre-COVID-19, COVID-19 and post-COVID-19 eras.

View Article and Find Full Text PDF
Article Synopsis
  • - Breast cancer is a significant global health issue, with 2.3 million new cases and 685,000 deaths reported in 2020; projections suggest this could rise to 3 million cases and 1 million deaths by 2040.
  • - A study in rural Rajasthan, India, involved 2023 participants to assess breast cancer prevalence, finding that 2 out of 3 positive screening cases had breast cancer, resulting in a very low prevalence rate of 0.0009 (98 per 100,000).
  • - The research highlights the need for greater awareness, early detection, and improved healthcare access in rural areas, emphasizing that challenges like limited resources and delayed diagnoses should be addressed with better screening and healthcare
View Article and Find Full Text PDF

Introduction: The ongoing repercussions of the COVID-19 pandemic include potentially deleterious impacts on bone health.

Aim: This research aimed to ascertain the effects of COVID-19 on the bone health of obese and non-obese Indian individuals.

Methods: We executed a case-control study enrolling individuals who recovered from COVID-19.

View Article and Find Full Text PDF

Background: The evolving challenge of persistent symptoms post-Coronavirus disease-2019 (COVID-19), particularly debilitating cardio-pulmonary manifestations, necessitates further exploration. Our study aimed to assess the cardio-pulmonary complications in patients a year after hospital discharge from severe COVID-19, contrasting these with findings from a non-COVID group.

Methods: The OneCoV2 study, a prospective, case-control study, was conducted at a tertiary care teaching hospital in northern India.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigated the connection between glycemic variability and depression in nondiabetic patients, highlighting that increased glycemic fluctuations could be linked to cardiovascular risks for those with depression.
  • Researchers used Flash Glucose Monitoring and the CES-D scale to classify patients into two groups based on depression severity, and analyzed several glycemic variability indices using specific software.
  • Results showed that patients with more severe depressive symptoms (CES-D ≥ 33) exhibited significantly higher levels of glycemic variability across multiple indices compared to those with milder symptoms, indicating a potential relationship between severe depression and glycemic control.
View Article and Find Full Text PDF
Article Synopsis
  • The study explores the relationship between frailty and health-related quality of life (HRQoL) in Asian patients with liver cirrhosis and sarcopenia, filling an important research gap.
  • A total of 138 patients were analyzed, revealing that those categorized as frail had significantly worse HRQoL scores compared to non-frail patients, indicating a notable impact of frailty on well-being.
  • The results showed strong negative correlations between frailty and key quality of life aspects such as activities, emotional function, and fatigue, with the frail group presenting higher odds ratios in these areas.
View Article and Find Full Text PDF

Aim And Scope: Glycemic variability (GV) denotes the fluctuations in the glucose values around the baseline. High glycemic variability is associated with a higher risk of diabetes-associated complications. In this study, we sought to determine the impact of therapeutic interventions based on flash glucose monitoring on rapid, short-term glycemic variability.

View Article and Find Full Text PDF

Objective: This retrospective study aims to investigate the impact of tocilizumab on inflammatory markers in patients with severe COVID-19. The effect on oxygenation was also assessed.

Methods: This study is a single-centre, retrospective cohort study conducted at NIMS hospital.

View Article and Find Full Text PDF