Serum human chorionic gonadotropin ratios for the detection of etoposide, methotrexate, dactinomycin, cyclophosphamide, and vincristine resistance in high-risk gestational trophoblastic neoplasia.

Aims: This study aimed to identify the optimal human chorionic gonadotropin (hCG) ratio in predicting etoposide, methotrexate, dactinomycin, cyclophosphamide, and vincristine resistance in women diagnosed with high-risk gestational trophoblastic neoplasia (GTN) and to compare the chemoresistant disease detection rate by using the optimal hCG ratio and traditional criteria.

Methods: Seventy-six women with primary high-risk GTN treated with etoposide, methotrexate, dactinomycin, cyclophosphamide, and vincristine in a tertiary-care center were included. The hCG ratio was determined by its serum pretreatment level divided by that before each cycle of chemotherapy.

Management and clinical outcomes of endometrial hyperplasia during a 13-year period in Songklanagarind Hospital.

Background: Endometrial hyperplasia has long been considered a precursor of endometrial cancer but there is no consensus regarding its management.

Objective: To identify management practices and evaluate outcomes of treatments for women diagnosed with endometrial hyperplasia (EH).

Material And Method: The medical records of endometrial hyperplasia at Songklanagarind Hospital between January 2000 and December 2012 were retrospectively reviewed.