Miro1 expression alters global gene expression, ERK1/2 phosphorylation, oxidation, and cell cycle progression.

Subcellular mitochondrial positioning in cells is necessary for localized energy and signaling requirements. Mitochondria are strategically trafficked throughout the cytoplasm via the actin cytoskeleton, microtubule motor proteins, and adaptor proteins. Miro1, an outer mitochondrial membrane adaptor protein, is necessary for attachment of mitochondria to microtubule motor proteins for trafficking.

Mitochondrial trafficking and redox/phosphorylation signaling supporting cell migration phenotypes.

Regulation of cell signaling cascades is critical in making sure the response is activated spatially and for a desired duration. Cell signaling cascades are spatially and temporally controlled through local protein phosphorylation events which are determined by the activation of specific kinases and/or inactivation of phosphatases to elicit a complete and thorough response. For example, A-kinase-anchoring proteins (AKAPs) contribute to the local regulated activity protein kinase A (PKA).

Local recruitment and fueling of the cellular powerplant to support cell invasion.

In this issue of Developmental Cell, Garde et al. demonstrate that polarized expression of the glucose transporter FGT-1, accompanied by a localized glucose gradient and mitochondrial recruitment to the basal membrane of the anchor cell (AC), supports localized ATP generation required for basement membrane (BM) invasion in C. elegans.

Miro1-mediated mitochondrial positioning supports subcellular redox status.

Mitochondria are strategically trafficked throughout the cell by the action of microtubule motors, the actin cytoskeleton and adapter proteins. The intracellular positioning of mitochondria supports subcellular levels of ATP, Ca and reactive oxygen species (ROS, i.e.

ERP differences in processing canonical and noncanonical finger-numeral configurations.

Finger-numeral configurations are used to represent numerosities, to count, and to do arithmetic across cultures. Previous research has distinguished between two forms of finger-numeral configurations; finger montring and finger counting. Montring refers to how people raise their fingers to show numerosities to others and usually serves a communicative function.