Fantastic wetlands and why to monitor them: Demonstrating the social and financial benefit potential of methane abatement through salt marsh restoration.

Salt marsh restoration has the potential to reduce greenhouse gas emissions thereby providing an opportunity for blue carbon crediting, but implementation has been limited to date because of insufficient data and validation. In this paper, we demonstrate the potential scale of methane emissions that could be avoided if salinity-reducing impairments are mitigated by applying findings from six salt marsh restoration sites in Massachusetts combined with a previously demonstrated application of the salt marsh salinity-methane relationship. We used calculations of these avoided emissions to estimate the social benefit of salt marsh restoration by calculating avoided costs.

Molecular-Level Dysregulation of Insulin Pathways and Inflammatory Processes in Peripheral Blood Mononuclear Cells by Circadian Misalignment.

Circadian misalignment due to night work has been associated with an elevated risk for chronic diseases. We investigated the effects of circadian misalignment using shotgun protein profiling of peripheral blood mononuclear cells taken from healthy humans during a constant routine protocol, which was conducted immediately after participants had been subjected to a 3-day simulated night shift schedule or a 3-day simulated day shift schedule. By comparing proteomic profiles between the simulated shift conditions, we identified proteins and pathways that are associated with the effects of circadian misalignment and observed that insulin regulation pathways and inflammation-related proteins displayed markedly different temporal patterns after simulated night shift.

Integrated data-driven cross-disciplinary framework to prevent chemical water pollution.

Access to a clean and healthy environment is a human right and a prerequisite for maintaining a sustainable ecosystem. Experts across domains along the chemical life cycle have traditionally operated in isolation, leading to limited connectivity between upstream chemical innovation to downstream development of water-treatment technologies. This fragmented and historically reactive approach to managing emerging contaminants has resulted in significant externalized societal costs.

This land is your land, this could be marsh land: Property parcel characteristics of marsh migration corridors in Rhode Island, USA.

Salt marshes, critical habitats offering many ecosystem services, are threatened by development, accelerated sea level rise (SLR) and other anthropogenic stressors that are projected to worsen. As seas rise, some salt marshes can migrate inland if there is adjacent, permeable, undeveloped land available. Facilitating marsh migration is necessary for coastal resilience efforts, but extensive coastal development can make finding suitable migration corridors challenging.

Proteomic Determinants of Variation in Cholesterol Efflux: Observations from the Dallas Heart Study.

High-density lipoproteins (HDLs) are promising targets for predicting and treating atherosclerotic cardiovascular disease (ASCVD), as they mediate removal of excess cholesterol from lipid-laden macrophages that accumulate in the vasculature. This functional property of HDLs, termed cholesterol efflux capacity (CEC), is inversely associated with ASCVD. HDLs are compositionally diverse, associating with >250 different proteins, but their relative contribution to CEC remains poorly understood.

Using cellular device location data to estimate visitation to public lands: Comparing device location data to U.S. National Park Service's visitor use statistics.

Understanding human use of public lands is essential for management of natural and cultural resources. However, compiling consistently reliable visitation data across large spatial and temporal scales and across different land managing entities is challenging. Cellular device locations have been demonstrated as a source to map human activity patterns and may offer a viable solution to overcome some of the challenges that traditional on-the-ground visitation counts face on public lands.

Considerations for Using Alternative Technologies in Nutrient Management on Cape Cod: Beyond Cost and Performance.

Mitigating non-point source nitrogen in coastal estuaries is economically, environmentally, logistically, and socially challenging. On Cape Cod, Massachusetts, nitrogen management includes both traditional, centralized wastewater treatment and sewering as well as a number of alternative technologies. We conducted semi-structured interviews with 37 participants from governmental and non-governmental organizations as well as related industries to identify the barriers and opportunities for the use of alternative technologies to mitigate nitrogen pollution.

Factors in homeowners' willingness to adopt nitrogen-reducing innovative/alternative septic systems.

When environmental mitigation requires individual adoption, engagement approaches centered on cost effectiveness and technological efficiency alone are often insufficient. Through focus groups with adopters and prospective adopters, this research identifies factors influencing homeowners' willingness to adopt Innovative/Alternative (I/A) septic systems for nitrogen reduction. We apply concepts from technology adoption and behavior change models as a framework for illustrating the homeowner decision-making process around I/A adoption.

Human cerebrospinal fluid contains diverse lipoprotein subspecies enriched in proteins implicated in central nervous system health.

Lipoproteins in cerebrospinal fluid (CSF) of the central nervous system (CNS) resemble plasma high-density lipoproteins (HDLs), which are a compositionally and structurally diverse spectrum of nanoparticles with pleiotropic functionality. Whether CSF lipoproteins (CSF-Lps) exhibit similar heterogeneity is poorly understood because they are present at 100-fold lower concentrations than plasma HDL. To investigate the diversity of CSF-Lps, we developed a sensitive fluorescent technology to characterize lipoprotein subspecies in small volumes of human CSF.

A pipeline for testing drug mechanism of action and combination therapies: From microarray data to simulations via Linear-In-Flux-Expressions: Testing four-drug combinations for tuberculosis treatment.

Computational methods are becoming commonly used in many areas of medical research. Recently, the modeling of biological mechanisms associated with disease pathophysiology have benefited from approaches such as Quantitative Systems Pharmacology (briefly QSP) and Physiologically Based Pharmacokinetics (briefly PBPK). These methodologies show the potential to enhance, if not substitute animal models.

Hazardous and contaminated sites within salt marsh migration corridors in Rhode Island, USA.

As salt marshes attempt to migrate upland due to sea level rise, they will encounter many kinds of land development and infrastructure in highly populated, urbanized coastal communities. Hazardous and contaminated sites (HCSs) -- facilities and infrastructure that store, use, or release harmful substances -- are particularly concerning obstacles to salt marsh migration because of their potential to release contaminants if their structural integrity is compromised. Inventorying HCSs within migration pathways can inform coastal resilience planning.

A Dynamic Modeling Approach to Estimate Nitrogen Loading in Coastal Bays on Cape Cod, Massachusetts, USA.

Solving estuarine water quality problems on Cape Cod, Massachusetts, or elsewhere, is difficult. Nitrogen from septic systems takes years to decades to travel by groundwater to estuaries, depending on local hydrogeology, meaning that nitrogen loading in future years may exceed current conditions. We created a dynamic nitrogen model of Cape Cod's 54 estuaries to better understand 1.

Coastal Recreation in Southern New England: Results from a Regional Survey.

This paper presents a summary of coastal recreation of New England residents from a survey conducted in the summer of 2018. The management of New England's coasts benefits from understanding the value of coastal recreation and the factors influencing recreational behavior. To address this need, the survey collected the geographic location and trip details for both day and overnight visits to any type of location on the New England coast for a range of water recreation activities, providing a comprehensive view of coastal recreation in the region.

Evaluating water quality impacts on visitation to coastal recreation areas using data derived from cell phone locations.

Linking human behavior to environmental quality is critical for effective natural resource management. While it is commonly assumed that environmental conditions partially explain variation in visitation to coastal recreation areas across space and time, scarce and inconsistent visitation observations challenge our ability to reveal these connections. With the ubiquity of mobile phone usage, novel sources of digitally derived data are increasingly available at a massive scale.

Opportunities and Challenges for Including Oyster-Mediated Denitrification in Nitrogen Management Plans.

Nitrogen pollution is one of the primary threats to coastal water quality globally, and governmental regulations and marine policy are increasingly requiring nitrogen remediation in management programs. Traditional mitigation strategies (e.g.

Geographies of Dirty Water: Landscape-Scale Inequities in Coastal Access in Rhode Island.

Across the United States, development, gentrification, and water quality degradation have altered our access to the coasts, redistributing the benefits from those spaces. Building on prior coastal and green space access research, we examined different populations' relative travel distances to all public coastal access and to public marine swimming beaches across the state of Rhode Island, by race, ethnicity, and socioeconomics. Next, we assessed relative travel distances to high quality public coastal amenities, i.

When, where, and how to intervene? Trade-offs between time and costs in coastal nutrient management.

Policies and regulations designed to address nutrient pollution in coastal waters are often complicated by delays in environmental and social systems. Social and political inertia may delay implementation of cleanup projects, and even after the best nutrient pollution management practices are developed and implemented, long groundwater travel times may delay the impact of inland or upstream interventions. These delays and the varying costs of nutrient removal alternatives used to meet water quality goals combine to create a complex dynamic decision problem with trade-offs about when, where, and how to intervene.

Messaging on Slow Impacts: Applying Lessons Learned from Climate Change Communication to Catalyze and Improve Marine Nutrient Communication.

Building publics' understanding about human-environmental causes and impacts of nutrient pollution is difficult due to the diverse sources and, at times, extended timescales of increasing inputs, consequences to ecosystems, and recovery after remediation. Communicating environmental problems with "slow impacts" has long been a challenge for scientists, public health officials, and science communicators, as the time delay for subsequent consequences to become evident dilutes the sense of urgency to act. Fortunately, scientific research and practice in the field of climate change communication has begun to identify best practices to address these challenges.

History and Future Perspectives on the Discipline of Quantitative Systems Pharmacology Modeling and Its Applications.

Mathematical biology and pharmacology models have a long and rich history in the fields of medicine and physiology, impacting our understanding of disease mechanisms and the development of novel therapeutics. With an increased focus on the pharmacology application of system models and the advances in data science spanning mechanistic and empirical approaches, there is a significant opportunity and promise to leverage these advancements to enhance the development and application of the systems pharmacology field. In this paper, we will review milestones in the evolution of mathematical biology and pharmacology models, highlight some of the gaps and challenges in developing and applying systems pharmacology models, and provide a vision for an integrated strategy that leverages advances in adjacent fields to overcome these challenges.

A Two-Step Model of Human Entrainment: A Quantitative Study of Circadian Period and Phase of Entrainment.

One of the essential characteristics of an authentic circadian clock is that the free-running period sustains an approximately 24-hour cycle. When organisms are exposed to an external stimulus, the endogenous oscillators synchronize to the cycling environment signal in a process known as entrainment. These environmental cues perform an important role in resetting the phase and period of the circadian clock.

Using data derived from cellular phone locations to estimate visitation to natural areas: An application to water recreation in New England, USA.

We introduce and validate the use of commercially available human mobility datasets based on cell phone locations to estimate visitation to natural areas. By combining this data with on-the-ground observations of visitation to water recreation areas in New England, we fit a model to estimate daily visitation for four months to more than 500 sites. The results show the potential for this new big data source of human mobility to overcome limitations in traditional methods of estimating visitation and to provide consistent information at policy-relevant scales.

Quantifying Recreational Use of an Estuary: A Case Study of Three Bays, Cape Cod, USA.

Estimates of the types and number of recreational users visiting an estuary are critical data for quantifying the value of recreation and how that value might change with variations in water quality or other management decisions. However, estimates of recreational use are minimal and conventional intercept surveys methods are often infeasible for widespread application to estuaries. Therefore, a practical observational sampling approach was developed to quantify the recreational use of an estuary without the use of surveys.

Valuing Coastal Beaches and Closures Using Benefit Transfer: An Application to Barnstable, Massachusetts.

Each year, millions of Americans visit beaches for recreation, resulting in significant social welfare benefits and economic activity. Considering the high use of coastal beaches for recreation, closures due to bacterial contamination have the potential to greatly impact coastal visitors and communities. We used readily-available information to develop two transferable models that, together, provide estimates for the value of a beach day as well as the lost value due to a beach closure.

Optimal Groundwater Extraction under Uncertainty and a Spatial Stock Externality.

We introduce a model that incorporates two important elements to estimating welfare gains from groundwater management: stochasticity and a spatial stock externality. We estimate welfare gains resulting from optimal management under uncertainty as well as a gradual stock externality that produces the dynamics of a large aquifer being slowly exhausted. This groundwater model imposes an important aspect of a depletable natural resource without the extreme assumption of complete exhaustion that is necessary in a traditional single cell (bathtub) model of groundwater extraction.