Publications by authors named "Nathaniel F Schemmel"
Article Synopsis
- Coronaviruses can originate from animals and cause serious illnesses in both humans and animals, with a key protein called Mac1 playing a role in viral replication and interferon inhibition.
- Researchers discovered a compound, MCD-628, that inhibits Mac1 but found its effectiveness was limited due to poor permeability.
- By creating more hydrophobic derivatives, they identified four compounds that successfully inhibited Mac1 and reduced replication of coronaviruses, confirming their specificity through drug-resistance mutations, but this resistance came at a cost to the virus's overall fitness.
