Peripheral ulcerative keratitis and corneal melt: a 10-year single center review with historical comparison.

Purpose: Management of noninfectious ulcerative keratitis (UK) and associated systemic disorders has changed over recent years. This study aimed to analyze a recent cohort of patients with UK in this context.

Methods: The case notes of all the patients attending a specialist corneal immunosuppression clinic between June 2002 and July 2012 were reviewed.

In vitro quantification of the stiffening effect of corneal cross-linking in the human cornea using radial shearing speckle pattern interferometry.

Purpose: To quantify the magnitude of the stiffening effect of corneal cross-linking (CXL) by studying intact human corneas exposed to physiological pressure transients.

Methods: Nine organ-cultured human corneas mounted in artificial anterior chambers were studied. A radial shearing speckle pattern interferometer was used to measure changes in corneal strain following an increase in artificial anterior chamber pressure from 15.

Effects of variation in depth and side cut angulations in LASIK and thin-flap LASIK using a femtosecond laser: a biomechanical study.

Purpose: To study the corneal biomechanical effects of varying LASIK flap depth and side cut angulations and evaluate the relative contribution of the lamellar and side cuts using a femtosecond laser and radial shearing speckle pattern interferometry (RSSPI).

Methods: Forty-two organ-cultured human corneas were divided into a control group and three investigative groups, each undergoing different incision types at both 90- and 160-μm depth using a femtosecond laser. In the first group, typical LASIK flaps were created; in the second group, only the bed was cut (delamination); and in the third group, side cuts alone were affected.

First eye prediction error improves second eye refractive outcome results in 2129 patients after bilateral sequential cataract surgery.

Objective: To define theoretical correction factors for second-eye intraocular lens (IOL) power adjustment based on first eye refractive prediction error (PE).

Design: Database study.

Participants: We included 2129 patients who underwent bilateral sequential phacoemulsification cataract surgery with the same IOL model.

Formula choice: Hoffer Q, Holladay 1, or SRK/T and refractive outcomes in 8108 eyes after cataract surgery with biometry by partial coherence interferometry.

Purpose: To assess how intraocular lens (IOL) formula choice affects refractive outcomes after cataract surgery using IOLMaster biometry.

Setting: Department of Ophthalmology, Gloucestershire Hospitals NHS Foundation Trust, Cheltenham, United Kingdom.

Design: Database study.

Intraocular lens formula constant optimization and partial coherence interferometry biometry: Refractive outcomes in 8108 eyes after cataract surgery.

Purpose: To assess the benefits of intraocular lens (IOL)-constant optimization for IOLMaster biometry on refractive outcomes after cataract surgery for all surgeons and individual surgeons, define acceptable levels of error in IOL-constant optimization, and calculate the minimum number of eyes required for IOL-constant optimization.

Setting: Department of Ophthalmology, Gloucestershire Hospitals NHS Foundation Trust, Cheltenham, United Kingdom.

Design: Database study.

Age-related differences in the elasticity of the human cornea.

Purpose: The goal of this study was to determine age-related variation in the elasticity of the human cornea using nondestructive means.

Methods: Organ cultured human corneoscleral buttons were studied. Changes in strain were measured with a radial shearing speckle pattern interferometer after an increase in intraocular pressure from 15.

3D collagen orientation study of the human cornea using X-ray diffraction and femtosecond laser technology.

Purpose: To study the distribution and predominant orientations of fibrillar collagen at different depths throughout the entire thickness of the human cornea. This information will form the basis of a full three-dimensional reconstruction of the preferred orientations of corneal lamellae.

Methods: Femtosecond laser technology was used to delaminate the central zones of five human corneas into three separate layers (anterior, mid, and posterior stroma), each with predetermined thicknesses.

Subperiosteal orbital hemorrhage following self-strangulation.

Subperiosteal orbital hematomas are uncommon. The delayed presentation of such an event is described in an anticoagulated patient who attempted self-strangulation. Despite the initial presence of a relative afferent pupillary defect, excellent visual recovery occurred, demonstrating the importance of prompt recognition and treatment.

Branch retinal vein occlusion and fluoxetine.

A case of branch retinal vein occlusion associated with fluoxetine-induced secondary hypertension is described. Although an infrequent complication of selective serotonin reuptake inhibitor therapy, it is important that ophthalmologists are aware that these agents can cause hypertension because this class of drugs is widely prescribed.

Electrolysis-needle cauterization of corneal vessels in patients with lipid keratopathy.

Purpose: To describe a technique of corneal vessel occlusion by using electrolysis-needle cautery.

Methods: A prospective case series of three patients.

Results: Corneal vessels were successfully occluded in all patients.

Recovery from macular phototoxicity after corneal triple procedure.

Purpose: Visual recovery from macular phototoxicity in 2 cases after prolonged exposure to operating microscope light from uncomplicated corneal triple-procedure surgery. Recovery is discussed in the context of repair and regeneration.

Methods: Retrospective case reports.

Ultrastructural evaluation of explanted opacified Hydroview (H60M) intraocular lenses.

Aim: To describe the ultrastructural appearance of explanted opacified Hydroview H60M intraocular lenses.

Methods: 14 explanted lenses were examined by scanning electron microscopy, and their appearance compared with a non-implanted H60M lens from the same time period. Wavelength-dispersive x ray spectroscopy (WDX) was performed on two opacified lenses.