Publications by authors named "Nathaniel D Jackson"
Article Synopsis
- Researchers are investigating therapeutic monoclonal antibodies (mAbs) targeting different vulnerable sites on the SARS-CoV-2 spike protein to prevent the virus from escaping treatment and to enhance protection against variants.
- They discovered several effective neutralizing antibodies that can be used in combination, showing strong protection in a mouse model of infection.
- One specific RBD antibody, WRAIR-2125, was particularly effective against all major variants and, when used with other mAbs, helped prevent the virus from evading the immune response.
Protein-only ribonuclease P (PRORP) is an enzyme responsible for catalyzing the 5' end maturation of precursor transfer ribonucleic acids (pre-tRNAs) encoded by various cellular compartments in many eukaryotes. PRORPs from plants act as single-subunit enzymes and have been used as a model system for analyzing the function of the metazoan PRORP nuclease subunit, which requires two additional proteins for efficient catalysis. There are currently few molecular details known about the PRORP-pre-tRNA complex.
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