Perineural Adductor Canal Catheter Placement for Prevention of Complex Regional Pain Syndrome-I Exacerbation After Knee Arthroscopy: A Case Report.

Arthroscopic knee surgery is a common trigger for lower extremity complex regional pain syndrome (CRPS). Few studies assess nerve block catheters for CRPS treatment; they do not appear to be studies of regional anesthesia to treat CRPS that occurs after knee surgery. We present a case of CRPS-I triggered by knee surgery on multiple prior occasions but finally prevented by perineural adductor canal catheter placement.

Risk of Mortality between Untreated and Treated Papillary Thyroid Cancer: A Matched Cohort Analysis.

Objectives: To examine the association between treatment status and mortality risk among patients with papillary thyroid cancer (PTC).

Methods: We identified 3,679 adults with PTC. Thirty-one untreated patients were matched to 155 treated patients.

Understanding the natural history of papillary thyroid cancer: Case series.

Background: Papillary thyroid cancer (PTC) incidence continues to rise. We describe the natural history of untreated PTC patients.

Methods: Retrospective case series of 31 untreated PTC patients.

Factors Impacting Online Ratings for Otolaryngologists.

Objective: To identify factors associated with online patient ratings and comments for a nationwide sample of otolaryngologists.

Methods: Ratings, demographic information, and written comments were obtained for a random sample of otolaryngologists from HealthGrades.com and Vitals.

Sinus procedures in the Medicare population from 2000 to 2014: A recent balloon sinuplasty explosion.

Objective: To describe sinus procedure trends from 2000 to 2014, particularly following the introduction of balloon sinuplasty Common Procedural Technology (CPT) codes in 2011.

Study Design: Retrospective review of Medicare billing data available to the public.

Methods: Procedure and beneficiary data from 2000 to 2014 and provider data from 2012 to 2014 were obtained online from the Centers for Medicare and Medicaid Services.

Fully automatic analysis of the knee articular cartilage T1ρ relaxation time using voxel-based relaxometry.

Purpose: To develop and compare with the classical region of interest (ROI)-based approach a fully automatic, local, and unbiased way of studying the knee T1ρ relaxation time by creating an atlas and using voxel-based relaxometry (VBR) in osteoarthritis (OA) and anterior cruciate ligament (ACL) subjects.

Materials And Methods: In this study 110 subjects from two cohorts: 1) Mild OA 40 patients with mild-OA Kellgren-Lawrence (KL) ≤ 2 and 15 controls KL ≤ 1; 2) ACL cohort (a model for early OA): 40 ACL-injured patients imaged prior to ACL reconstruction and 1-year postsurgery and 15 controls are analyzed. All the subjects were acquired at 3T with a protocol that includes: 3D-FSE (CUBE) and 3D-T1ρ .

Zonal differences in meniscus MR relaxation times in response to in vivo static loading in knee osteoarthritis.

This study assessed the effects of static loading on MRI relaxation times of menisci in individuals with and without radiographic knee OA. High-resolution fast spin-echo (FSE) and T(1ρ)/T(2) relaxation time MR sequences were obtained with and without loading at 50% body weight in 124 subjects. T(1ρ)/T(2) relaxation times were calculated in menisci, and meniscus lesions were assessed through clinical grading.

Are There Sex Differences in Knee Cartilage Composition and Walking Mechanics in Healthy and Osteoarthritis Populations?

Background: Women are at a greater risk for knee osteoarthritis (OA), but reasons for this greater risk in women are not well understood. It may be possible that differences in cartilage composition and walking mechanics are related to greater OA risk in women.

Questions/purposes: (1) Do women have higher knee cartilage and meniscus T1ρ than men in young healthy, middle-aged non-OA and OA populations? (2) Do women exhibit greater static and dynamic (during walking) knee loading than men in young healthy, middle-aged non-OA and OA populations?

Methods: Data were collected from three cohorts: (1) young active (<35 years) (20 men, 13 women); (2) middle-aged (≥35 years) without OA (Kellgren-Lawrence [KL] grade < 2) (43 men, 65 women); and (3) middle-aged with OA (KL>1) (18 men, 25 women).

Physical activity and spatial differences in medial knee T1rho and t2 relaxation times in knee osteoarthritis.

Study Design: Cross-sectional.

Objectives: To investigate the association between knee loading- related osteoarthritis (OA) risk factors (obesity, malalignment, and physical activity) and medial knee laminar (superficial and deep) T1rho and T2 relaxation times.

Background: The interaction of various modifiable loading-related knee risk factors and cartilage health in knee OA is currently not well known.

Somatic copy number mosaicism in human skin revealed by induced pluripotent stem cells.

Reprogramming somatic cells into induced pluripotent stem cells (iPSCs) has been suspected of causing de novo copy number variation. To explore this issue, here we perform a whole-genome and transcriptome analysis of 20 human iPSC lines derived from the primary skin fibroblasts of seven individuals using next-generation sequencing. We find that, on average, an iPSC line manifests two copy number variants (CNVs) not apparent in the fibroblasts from which the iPSC was derived.