Publications by authors named "Nathania Hartojo"
Sci Immunol
December 2021
Article Synopsis
- The study investigates the adaptive immune response by examining the naive B cell repertoire's ability to recognize and target SARS-CoV-2, focusing on the receptor binding domain (RBD).
- Researchers isolated naive B cells from eight human donors and used single-cell B cell receptor sequencing to analyze their diversity and specificity against various SARS-CoV-2 variants and related coronaviruses.
- Structural analysis revealed that certain naive antibodies could effectively signal B cell activation and, after optimization, showed strong neutralization capabilities against SARS-CoV-2, potentially aiding in the development of broad coronavirus vaccines.
Article Synopsis
- * Researchers isolated naive B cells from seronegative donors and analyzed their gene usage, finding a diverse range that could help in targeting the virus effectively.
- * They discovered that both naive and engineered antibodies could neutralize SARS-CoV-2 and suggest that understanding these B cells could aid in creating universal vaccines against coronaviruses.
