Publications by authors named "Nathanael Marrie"
Article Synopsis
- - The study focuses on dysbetalipoproteinemia (DBL), a lipid disorder linked to cardiovascular disease risk, especially in individuals with the ε2ε2 genotype, and evaluates the effectiveness of nine different screening algorithms, including a new one developed by the researchers.
- - Patients were classified into three groups based on their genetic background and the diagnostic performance of the algorithms was assessed against a gold standard of specific triglyceride levels and genotypes.
- - The findings indicate that the "Hospices Civils de Lyon (HCL) algorithm" demonstrated superior diagnostic ability for detecting DBL in both ε2ε2 and rare variant carriers compared to other algorithms, highlighting the need for further investigation into the accuracy of these screening methods.
Objectives: Low-density lipoprotein cholesterol (LDL-C) concentration was calculated for many years using the Friedewald equation, but those from Sampson and extended-Martin-Hopkins perform differently. Their accuracy in fasting hypertriglyceridemia and non-fasting state were compared and the clinical impact of implementing these equations on risk classification and on the setting of lipid treatment goals was assessed.
Methods: Seven thousand six standard lipid profiles and LDL-C concentrations measured after ultracentrifugation (uLDL-C) were retrospectively included.