Publications by authors named "Nathanael J Kuzio"
ACS Med Chem Lett
February 2019
Article Synopsis
- DNA methylation is a key epigenetic modification that regulates gene expression and is affected by processes like cell differentiation and diseases such as cancer.
- The TET enzyme family facilitates DNA demethylation, and this study focuses on developing novel inhibitors targeting TET enzymes, which have been underexplored in research.
- A promising compound called Bobcat339 was identified as a potential TET1 and TET2 inhibitor without affecting DNMT3a, providing new tools for epigenetic research and potential therapies targeting gene regulation.
