Publications by authors named "Nathan Van Bibber"
Background: People living with HIV (PWH) have improved life expectancy due to effective HIV therapy but still experience immune impairment (e.g., altered CD4/CD8 T-cells).
View Article and Find Full Text PDFEpstein-Barr virus (EBV) is associated with a diverse range of lymphomas. EBV-specific T-cell (EBVST) infusions have shown promise in safety and clinical effectiveness in treating EBV-associated lymphomas; however, not all patients respond to T-cell immunotherapies. To identify EBV-antigen specific antibody responses associated with clinical outcomes, we comprehensively characterized the antibody responses to the complete EBV proteome using a custom protein microarray in 56 EBV-associated lymphoma patients who received EBVST infusions enrolled in Phase I clinical trials.
View Article and Find Full Text PDFArticle Synopsis
- Epstein-Barr virus (EBV) is linked to various types of lymphomas, and while EBV-specific T-cell (EBVST) therapies have shown effectiveness, not all patients benefit from them.
- A study analyzing immune responses in 56 lymphoma patients receiving EBVST treatments discovered distinct antibody profiles that differentiate responders from non-responders, particularly at 3 months after treatment.
- The research identified 10 specific IgG antibodies that can predict clinical responses, suggesting that these EBV-directed antibodies may serve as biomarkers for patient outcomes in EBV-associated lymphoma treatments.
Article Synopsis
- The COVID-19 pandemic disrupted cancer care, particularly affecting immunosuppressed patients, leading to delays in treatment initiation for people living with HIV (PLWH) compared to the general cancer population (GCP) and those with a history of solid organ transplants (SOT).
- A study analyzed data from US patients with various cancer types between 2018 and 2021, finding that PLWH faced significant delays—about one month longer—when starting cancer treatment during the first year of the pandemic.
- The delays were noted across different treatment types, indicating a potential negative impact on cancer outcomes for PLWH, highlighting the need for increased attention from both patients and providers as the healthcare system continues to deal
Article Synopsis
- * Core duplicon gene (CDG) families consist of these duplications and are interesting because they contain shared "core" DNA while potentially adding new protein functions and exhibiting multifunctionality in their encoded proteins.
- * A study of 10 CDG families revealed that many of their proteins are highly disordered, meaning they lack a fixed structure, which may facilitate protein interactions and various modifications after translation.
Article Synopsis
- - Tetratricopeptide repeats (TPRs) are protein motifs made up of 34 amino acids, commonly found in proteins that facilitate interactions between other proteins, typically organized in stacks of 2 to 20 repeats.
- - Many repeat-containing proteins, including TPRs, exhibit high levels of intrinsic disorder, meaning they lack a fixed structure and can be flexible in their functions and interactions.
- - A study of 166 human TPR proteins showed varying degrees of intrinsic disorder, highlighting the presence of disordered regions that play essential roles in protein interactions and can be modified through posttranslational modifications.