Publications by authors named "Nathan McChesney"
Background: Formulation screening is essential to experimentally balance stability and viscosity in high-concentration mAb formulations. We developed a high-throughput approach with automated sample preparation and analytical workflows to enable the integrated assessment of excipient compatibility and viscosity of mAb formulations.
Methods: Ninety-six formulations of a trastuzumab biosimilar were screened by combining 8 types of excipient modifiers with 4 types of buffers across a pH range of 4.
Article Synopsis
- Dysfunction in the peripheral auditory nerve (AN) can lead to abnormal processing in the central auditory system, which is linked to heightened sound sensitivity often seen in autism spectrum disorder (ASD).
- The MEF2C transcription factor is crucial for auditory development, and its mutations can lead to a haploinsufficiency syndrome associated with ASD and related cognitive deficits.
- Research shows that a mouse model with MEF2C deficits exhibits auditory nerve impairments, highlighting cellular changes and inflammation that may contribute to both auditory dysfunction and ASD symptoms.