Publications by authors named "Nathan L Kindja"
Article Synopsis
- The voltage-gated calcium channel (VGCC) is made up of an α1 subunit and three auxiliary subunits, with the β subunit being crucial for moving the α1 subunit to the cell membrane and is extensively studied in calcium signaling.
- VGCCs play a critical role in calcium ion movement within neurons, influencing processes like dendritic spine plasticity, with dysfunction in this signaling linked to neurodevelopmental disorders such as schizophrenia.
- Overexpressing the β4 subunit in a mouse model reduced the density of small dendritic spines, with notable sex differences in this effect, indicating that interactions with other VGCC subunits, like β1b in males, may help protect against this reduction.
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View Article and Find Full Text PDFDendritic spines are small protrusions on dendrites that endow neurons with the ability to receive and transform synaptic input. Dendritic spine number and morphology are altered as a consequence of synaptic plasticity and circuit refinement during adolescence. Dendritic spine density (DSD) is significantly different based on sex in subcortical brain regions associated with the generation of sex-specific behaviors.
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