Publications by authors named "Nathan L DeBono"
Objective: We performed a meta-analysis of epidemiological results for the association between occupational exposure as a firefighter and cancer as part of the broader evidence synthesis work of the program.
Methods: A systematic literature search was conducted to identify cohort studies of firefighters followed for cancer incidence and mortality. Studies were evaluated for the influence of key biases on results.
Article Synopsis
- The study investigates the link between occupational radon exposure among male miners in Ontario and the risk of neurodegenerative diseases like Alzheimer's and Parkinson's.
- Researchers utilized historical job records to assess radon exposure from 1915 to 1988 and analyzed neurodegenerative outcomes from 1992 to 2018 with Poisson regression models.
- Results showed increased risks of Alzheimer's and Parkinson's at lower exposure levels, but no clear relationship for higher exposures or with motor neuron disease, indicating inconsistent findings in radon exposure's impact.
Objective: Firefighters and police often work in high-stress, complex environments with known and suspected carcinogenic exposures. We aimed to characterise cancer incidence among firefighters and police.
Methods: The Occupational Disease Surveillance System (ODSS) was used to identify workers employed as firefighters or police in Ontario.
Objectives: We estimated associations between respirable aluminum exposure through McIntyre Powder (MP), a fine-sized aluminum and aluminum compound powder, and neurological disease in a retrospective cohort of mining workers from Ontario, Canada. Outcomes included Alzheimer's disease, Alzheimer's with other dementias, Parkinson's disease, parkinsonism, and motor neuron disease.
Methods: The cohort was created by linking a database of mining workers' work history to healthcare records.
Objective: We sought to characterize detailed patterns of mesothelioma and asbestosis incidence in the workforce as part of an occupational disease surveillance program in Ontario, Canada.
Methods: The Occupational Disease Surveillance System (ODSS) cohort was established using workers' compensation claims data and includes 2.18 million workers employed from 1983 to 2014.
Objectives: We examined employment in mining occupations and industries and its association with neurological disease incidence in a linkage cohort from Ontario, Canada. Outcomes included Alzheimer's disease (alone and with other dementias), Parkinson's disease, parkinsonism, motor neuron disease and amyotrophic lateral sclerosis (ALS).
Methods: The Occupational Disease Surveillance System cohort was created by linking workers' compensation data and healthcare usage records.
Objective: Occupational exposure to agents in plastics and rubber manufacturing has been associated with elevated risk of certain cancers. We sought to evaluate cancer risk among workers employed in occupations and industries with these exposures as part of an ongoing surveillance programme in Ontario, Canada.
Methods: The Occupational Disease Surveillance System (ODSS) cohort was established using workers' compensation claims data and includes 2.
Objectives: There are established methods for occupational epidemiological cohort analysis, such as proportional hazards regression, that are well suited to aetiological research and yield parameter estimates that allow for succinct communication among academics. However, these methods are not necessarily well suited for evaluation of health impacts of policy choices and communication to decision makers. An informed decision about a policy that impacts health and safety requires a valid estimate of the policy's potential impact.
View Article and Find Full Text PDFPurpose: The use of combined estrogen-progestin menopausal hormone therapy (MHT) has been shown to increase the risk of breast cancer, however, recent observational studies have suggested that the association between MHT and breast cancer may be modified by race. The objective of this study was to investigate the association between MHT use and incidence of invasive breast cancer in Black and White women aged ≥40 years at diagnosis after accounting for racial differences in patterns of MHT use and formulation.
Methods: Data from the Carolina Breast Cancer Study, a population-based case-control study of Black and White women in North Carolina conducted between 1993 and 2001, was used to analyze 1474 invasive breast cancer cases and 1339 controls using unconditional logistic regression.