Publications by authors named "Nathan J Sacks"
DNA mismatch repair deficiency (MMRd) is associated with a high tumor mutational burden (TMB) and sensitivity to immune checkpoint blockade (ICB) therapy. Nevertheless, most MMRd tumors do not durably respond to ICB and critical questions remain about immunosurveillance and TMB in these tumors. In the present study, we developed autochthonous mouse models of MMRd lung and colon cancer.
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- Immune evasion in cancer is a major challenge, particularly in low tumor mutation burden (TMB) cancers like microsatellite stable (MSS) colorectal cancer (CRC), which are typically resistant to immunotherapy.
- Research indicates that MSS CRC tumors do express clonal neoantigens, but at lower levels compared to high TMB cancers.
- Enhancing the expression of these neoantigens can improve T cell activation and potentially lead to better tumor control, highlighting the importance of neoantigen levels in immune responses and cancer treatment effectiveness.