Publications by authors named "Nathan Herdener"
Objective: The aim of this study was to explore the impact of prior information on spatial prediction and understanding of variability.
Background: In uncertain spatial prediction tasks, such as hurricane forecasting or planning search-and-rescue operations, decision makers must consider the most likely case and the distribution of possible outcomes. Base performance on these tasks is varied (and in the case of understanding the distribution, often poor).
Article Synopsis
- The study aimed to understand how visualizations impact predictions of uncertain spatial trajectories and participant overconfidence in those predictions.
- Previous research found that predicting these trajectories is tough and often leads to overconfidence, suggesting that visual aids during training may help.
- Two experiments showed that while participants made more accurate predictions with visualizations, their advantage disappeared when the visuals were removed, indicating that visualizations can aid predictions but may also create dependency issues.
Article Synopsis
- The study investigates how human overconfidence affects the prediction of uncertain spatial trajectories, like those of hurricanes or ships, highlighting challenges in accurately predicting variance.
- Two experiments reveal that while participants can predict linear paths better than nonlinear ones, they consistently underestimate the uncertainty involved, showing overconfidence in their forecasts.
- The findings suggest that effectively predicting uncertainties in trajectories requires different skills than forecasting average paths, indicating a need for improved training and tools to enhance understanding of variability.
Age-associated dysregulation of sleep can be worsened by Alzheimer's disease (AD). AD and sleep restriction both impair cognition, yet it is unknown if mild chronic sleep restriction modifies the proteopathic processes involved in AD. The goal of this work was to test the hypothesis that sleep restriction worsens memory impairments, and amyloid β-peptide (Aβ) and pTau accumulations in the brain in a mouse model of AD, with a focus on a role for circulating glucocorticoids (GC).
View Article and Find Full Text PDFChronic stress may be a risk factor for developing Alzheimer's disease (AD), but most studies of the effects of stress in models of AD utilize acute adverse stressors of questionable clinical relevance. The goal of this work was to determine how chronic psychosocial stress affects behavioral and pathological outcomes in an animal model of AD, and to elucidate underlying mechanisms. A triple-transgenic mouse model of AD (3xTgAD mice) and nontransgenic control mice were used to test for an affect of chronic mild social stress on blood glucose, plasma glucocorticoids, plasma insulin, anxiety, and hippocampal amyloid β-particle (Aβ), phosphorylated tau (ptau), and brain-derived neurotrophic factor (BDNF) levels.
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