Publications by authors named "Nathan H Campbell"
Article Synopsis
- The study aimed to assess how well selected SNPs can predict certain HLA alleles linked to drug-induced hypersensitivity reactions (HSR) in various ethnic groups.
- Five HLA alleles were identified and tagged by seven specific SNPs, with DNA samples analyzed from diverse populations like African-Americans, Asians, Caucasians, and Hispanics.
- The results showed 100% sensitivity for predicting some HLA alleles, highlighting the effectiveness of SNP tagging as a method for anticipating HSR in different ethnicities.
Article Synopsis
- The FRO2 gene in Arabidopsis encodes a ferric chelate reductase that helps reduce iron at the root surface, enabling iron transport via the IRT1 transporter.
- Real-time RT-PCR analysis shows that FRO genes have distinct expression patterns: FRO2 and FRO5 in roots, FRO8 in shoots, and FRO3 in both, particularly elevated in iron-deficient conditions.
- Additionally, FRO6 expression decreases in shoots during copper limitation, while FRO3 expression increases, indicating that FRO family members play diverse roles in metal ion homeostasis across various plant tissues.
The Arabidopsis FRO2 gene encodes the low-iron-inducible ferric chelate reductase responsible for reduction of iron at the root surface. Here, we report that FRO2 and IRT1, the major transporter responsible for high-affinity iron uptake from the soil, are coordinately regulated at both the transcriptional and posttranscriptional levels. FRO2 and IRT1 are induced together following the imposition of iron starvation and are coordinately repressed following iron resupply.
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