Multilevel versus isolated endovascular tibial interventions for critical limb ischemia.

Objective: Endovascular interventions for critical limb ischemia (CLI) continue to have variable reported results. The purpose of this study is to determine the effect of disease level and distribution on the outcomes of tibial interventions.

Methods: A retrospective analysis of all tibial interventions done for CLI between 2006 and 2009 was performed.

Predictors of failure and success of tibial interventions for critical limb ischemia.

Objective: The efficacy of tibial artery endovascular intervention (TAEI) for critical limb ischemia (CLI) and particularly for wound healing is not fully defined. The purpose of this study is to determine predictors of failure and success for TAEI in the setting of CLI.

Methods: All TAEI for tissue loss or rest pain (Rutherford classes 4, 5, and 6) from 2004 to 2008 were retrospectively reviewed.

IL-1 regulates in vivo C-X-C chemokine induction and neutrophil sequestration following endotoxemia.

The influx of neutrophils into tissues in response to inflammatory stimuli involves C-X-C chemokines. Interleukin-1 (IL-1) stimulates chemokine production in vitro, but its role in vivo on chemokine production is not as clearly understood. We hypothesized that IL-1 mediates in vivo tissue C-X-C chemokine production induced by systemic lipopolysaccharide (LPS).