Publications by authors named "Nathan E Nachlas"
Objective: To assess the long-term safety and effectiveness of temperature-controlled radiofrequency (TCRF) neurolysis of the posterior nasal nerve (PNN), a minimally invasive treatment for chronic rhinitis.
Methods: A prospective, single-arm study of 129 patients at 16 centers (United States, Germany) was conducted. Patient-reported outcome measures were the 24-h reflective total nasal symptom score (rTNSS) and mini rhinoconjunctivitis quality of life questionnaire (MiniRQLQ).
Importance: Evidence is lacking from randomized clinical trials of hypoglossal nerve stimulation in obstructive sleep apnea (OSA).
Objective: To evaluate the safety and effectiveness of targeted hypoglossal nerve stimulation (THN) of the proximal hypoglossal nerve in patients with OSA.
Design, Setting, And Participants: This randomized clinical trial (THN3) was conducted at 20 centers and included 138 patients with moderate to severe OSA with an apnea-hypopnea index (AHI) of 20 to 65 events per hour and body mass index (calculated as weight in kilograms divided by height in meters squared) of 35 or less.
Article Synopsis
- The study aimed to evaluate the effectiveness and safety of the NuVent™ EM Balloon Sinus Dilation System in patients undergoing revision sinus surgery due to chronic rhinosinusitis (CRS).
- A total of 51 adults were enrolled across six clinical sites, with the device successfully navigating and dilating sinus ostia in all cases, treating a total of 121 sinuses without any device-related adverse events.
- The results indicate that the balloon dilation technique is safe and effective for revising frontal, maxillary, or sphenoid sinus surgeries, as there were no complications directly linked to the device used.
Clinical and Quality of Life Outcomes Following Temperature-Controlled Radiofrequency Neurolysis of the Posterior Nasal Nerve (RhinAer) for Treatment of Chronic Rhinitis.
Am J Rhinol Allergy
November 2022
Background: Temperature-controlled radiofrequency (TCRF) neurolysis of the posterior nasal nerve (PNN; RhinAer) is a minimally invasive treatment option for patients with chronic rhinitis.
Objective: To determine clinical outcomes and quality of life (QoL) following TCRF neurolysis of the PNN.
Methods: A prospective single-arm study of 129 patients with chronic rhinitis at 16 medical centers in the United States and Germany.
The aim of the study is to report outcomes after treatment of nasal valve collapse with a bioabsorbable nasal implant. It involves two prospective, multicenter, post-market studies evaluating long-term effectiveness of the LATERA implant for severe to extreme nasal obstruction. Participants underwent implant alone or with concomitant inferior turbinate reduction (ITR) and/or septoplasty.
View Article and Find Full Text PDFObjective: To examine 6-month outcomes for treatment of lateral nasal wall insufficiency with a bioabsorbable implant.
Study Design: Prospective, multicenter, nonrandomized, single-blinded study.
Methods: One hundred and one patients with severe-to-extreme class of Nasal Obstruction Symptom Evaluation (NOSE) scores were enrolled at 14 U.
Objectives/hypothesis: To assess balloon dilation of the Eustachian tube with Eustachian tube balloon catheter in conjunction with medical management as treatment for Eustachian tube dilatory dysfunction.
Study Design: In this prospective, multicenter, randomized, controlled trial, we assigned, in a 2:1 ratio, patients age 22 years and older with Eustachian tube dilatory dysfunction refractory to medical therapy to undergo balloon dilation of the Eustachian tube with balloon catheter in conjunction with medical management or medical management alone.
Methods: The primary endpoint was normalization of tympanogram at 6 weeks.