Publications by authors named "Nathan E Campbell"
Preeclampsia (PE), new-onset hypertension during pregnancy, affects up to 10% of pregnancies worldwide. Despite being the leading cause of maternal and fetal morbidity and mortality, PE has no cure beyond the delivery of the fetal-placental unit. Although the exact pathogenesis of PE is unclear, there is a strong correlation between chronic immune activation; intrauterine growth restriction; uterine artery resistance; dysregulation of the renin-angiotensin system.
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- Preeclampsia (PE) is characterized by hypertension and fetal growth restriction, and the reduced uterine perfusion pressure (RUPP) rat model mimics these conditions, showing elevated endothelin-1 (ET-1) and inflammation levels.
- The study aimed to analyze the effects of interleukin-2 (IL-2) on natural killer (NK) cell activity, blood pressure, and fetal growth in both normal pregnant (NP) and RUPP rats by administering varying doses of IL-2 or blocking IL-2 with basiliximab.
- While low and high doses of IL-2 lowered blood pressure and activated NK cells, they also led to reduced fetal weight and survival,