Publications by authors named "Nathan Doran"
Article Synopsis
- Sex and joint injury are significant risk factors for developing osteoarthritis (OA), with mouse studies showing that males often experience worse outcomes than females.
- Various injury models, such as meniscal and ligament damage, were assessed in male and female mice to evaluate how these injuries impact joint mechanics and progression of post-traumatic OA (ptOA).
- The study found that while joint laxity was similar between sexes, females exhibited greater joint stiffness; however, the changes in joint mechanics due to injuries were not primarily responsible for the differences in ptOA severity between male and female mice.
Microvascular pathology and ischemic lesions contribute substantially to neuronal dysfunction and loss that lead to Alzheimer disease (AD). To facilitate recovery, the brain stimulates neovascularization of damaged tissue via sprouting angiogenesis, a process regulated by endothelial cell (EC) sprouting and the EphB4/ephrinB2 system. Here, we show that in cultures of brain ECs, EphB4 stimulates the VE-cadherin/Rok-α angiogenic complexes known to mediate sprouting angiogenesis.
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