Molecular responses of vascular smooth muscle cells to paclitaxel-eluting bioresorbable stent materials.

We studied the influence of paclitaxel, eluted from poly(L-lactic acid) (PLLA), on cultured vascular smooth muscle cell (VSMC) proliferation as a model of bioresorbable stent-induced restenosis. We blended paclitaxel in cast PLLA films (P-PLLA), demonstrating controlled release of the drug, then studied VSMC adhesion, proliferation, and gene expression profiles. No difference in cell adhesion was found between P-PLLA and PLLA controls (105 +/- 12% of PLLA controls).

Protein-loaded bioresorbable fibers and expandable stents: Mechanical properties and protein release.

There is an increasing interest in bioresorbable polymeric stents for coronary, urethral and tracheal applications. These stents can support body conduits during their healing process and release biologically active agents from an internal reservoir to the surrounding tissue. A removal operation is not needed.

Skull base cerebrospinal fluid fistulas: a comprehensive diagnostic algorithm.

Objective: Our goal was to assess the efficacy of current diagnostic modalities in the management of skull base cerebrospinal fluid (CSF) fistulas.

Methods: We conducted a retrospective review of all patients presenting to our institution over the past 6 years with skull base CSF fistulas.

Results: Fifty-two patients were included in the study.

Suppurative complications of acute otitis media in the era of antibiotic resistance.

Objective: To review our experience with suppurative complications of acute otitis media (AOM) in the era of antibiotic resistance, given a perceived increase in the number of such cases in recent years requiring surgical intervention.

Design: Retrospective review of pediatric patients presenting with suppurative complications of AOM from January 1993 to June 2000.

Setting: Academic tertiary care children's medical center.