Serum and Soleus Metabolomics Signature of Knockout Mice to Identify Potential Biomarkers.

The transcription factor Krüppel-like factor 10 (), also known as Tieg1 for TGFβ (Inducible Early Gene-1) is known to control numerous genes in many cell types that are involved in various key biological processes (differentiation, proliferation, apoptosis, inflammation), including cell metabolism and human disease. In skeletal muscle, particularly in the soleus, deletion of the gene ( KO) resulted in ultrastructure fiber disorganization and mitochondrial metabolism deficiencies, characterized by muscular hypertrophy. To determine the metabolic profile related to loss of expression, we analyzed blood and soleus tissue using UHPLC-Mass Spectrometry.