Publications by authors named "Nathalie de Preville"

Article Synopsis
  • The COMET biobank project collects special tissue and blood samples from overweight patients to help with research on insulin sensitivity.
  • They set up a system to make sure all the samples are good quality and that the collection process is done the right way.
  • The results showed that the samples were collected properly, with good quality of DNA, RNA, and tissues, ensuring the project can be used for scientific studies safely.
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Background: Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease, which is associated with features of metabolic syndrome. NAFLD may progress in a subset of patients into nonalcoholic steatohepatitis (NASH) with liver injury resulting ultimately in cirrhosis and potentially hepatocellular carcinoma. Today, there is no approved treatment for NASH due to, at least in part, the lack of preclinical models recapitulating features of human disease.

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Article Synopsis
  • The study aims to identify a noninvasive method using the triglycerides and glucose (TyG) index as a predictor for nonalcoholic steatohepatitis (NASH) in obese patients, as diagnosing NASH typically requires a liver biopsy.
  • It analyzed 238 obese patients undergoing bariatric surgery, finding a 18.1% prevalence of NASH and a significant association between elevated TyG index levels and the presence of NASH, nonalcoholic fatty liver disease (NAFLD), and advanced fibrosis.
  • The TyG index combined with gamma-glutamyl transferase (GGT) demonstrated strong diagnostic performance for predicting NASH, indicating potential clinical utility for avoiding unnecessary liver biopsies in
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Constitution of biobank of human tissues requires careful handling and storage of biological material, to guarantee the quality of samples. Tissue preparation is also critical for further applications such as transcriptomic profiling. In this study, our aim was to evaluate the impact of different disruption techniques (FastPrep-24 instrument, GentleMACS dissociator, and syringe/needle) and homogenizing buffers (RLT versus QIAzol) on RNA purity and quality of metabolic tissues (adipose tissues, liver and skeletal muscle) present in the COMET Biobank.

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