Comparison of tests and procedures to build clinically relevant genotypic scores: application to the Jaguar study.

Objective: To compare non-parametric tests and procedures of selection in building clinically validated genotypic scores.

Design And Patients: In the Jaguar study, 111 patients on a stable antiretroviral regimen experiencing virological failure were randomized in the didanosine (ddI) arm to receive ddI for 4 weeks in addition to their current combination therapy.

Methods: The virological response was HIV-1 RNA reduction from baseline to week 4.