Publications by authors named "Nathalie Renotte"
Article Synopsis
- The study focuses on how SARS-CoV-2 evolves within immunocompromised patients, revealing new virus lineages resulting from prolonged infections, particularly the Omicron BF.7 sublineage that lasted over a year.
- Researchers analyzed eight samples from a single patient, discovering 87 genetic changes, including variants and deletions, indicating significant viral diversity within different parts of the respiratory system.
- The findings suggest that nasopharyngeal samples alone may not accurately reflect the full range of viral mutations, underlining the complexity of viral evolution in chronic infections.
Retroviruses are not expected to encode miRNAs because of the potential problem of self-cleavage of their genomic RNAs. This assumption has recently been challenged by experiments showing that bovine leukemia virus (BLV) encodes miRNAs from intragenomic Pol III promoters. The BLV miRNAs are abundantly expressed in B-cell tumors in the absence of significant levels of genomic and subgenomic viral RNAs.
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- Various animal models like rats, transgenic mice, and macaques have been used to study Human T-lymphotropic Virus (HTLV) pathogenesis, but they face limitations such as lack of disease relevance and specific immune responses.
- A comparative virology approach suggests studying related viruses like bovine leukemia virus (BLV), which is evolutionarily connected to HTLV-1.
- BLV causes lymphoproliferative disorders in cattle, offering insights into viral persistence, genetic factors in disease development, and potential new therapies for HTLV-related issues.*
Deltaretroviruses such as human T-lymphotropic virus type 1 (HTLV-1) and bovine leukemia virus (BLV) induce a persistent infection that remains generally asymptomatic but can also lead to leukemia or lymphoma. These viruses replicate by infecting new lymphocytes (i.e.
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