Publications by authors named "Nathalie Oliveira Santana"
Context: Ectopic acromegaly is a consequence of rare neuroendocrine tumors (NETs) that secrete GHRH. This abnormal GHRH secretion drives GH and IGF-1 excess, with a clinical presentation similar to classical pituitary acromegaly. Identifying the underlying cause for the GH hypersecretion in the setting of ectopic GHRH excess is, however, essential for proper management both of acromegaly and the NET.
View Article and Find Full Text PDFObjective: Genomic alterations in Hürthle cell carcinomas (HCC) include chromosomal losses, mitochondrial DNA mutations, and changes in the expression profile of the PI3K-AKT-mTOR and Wnt/β-catenin pathways. This study aimed at characterizing the mutational profile of HCC.
Methods: Next-generation sequencing (NGS) of 40 HCC using a 102-gene panel including, among others, the MAPK, PI3K-AKT-mTOR, Wnt/β-catenin, and Notch pathways.
Objective: Hürthle cell carcinomas (HCCs) of the thyroid have been recently reclassified as a separate entity due to their distinct clinical and molecular profiles. Few studies have assessed the ability of preoperative characteristics in differentiating HCCs from Hürthle cell adenomas (HCAs) due to the low prevalence of both lesions. This study aimed to compare the preoperative features of HCCs and HCAs and evaluate the diagnostic performance of ultrasound in distinguishing between both.
View Article and Find Full Text PDFObjective: The increasing incidence of thyroid nodules demands identification of risk factors for malignant disease. Several studies suggested the association of higher TSH levels with cancer, but influence of 25-hydroxyvitamin D (25OHD) is controversial. This study aimed to identify the relationship of thyroid cancer with higher TSH levels and hypovitaminosis D and to evaluate their influence on prognostic characteristics of papillary thyroid carcinomas (PTC).
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to assess the prevalence and genotypes of hepatitis C virus (HCV) among prisoners in Sergipe, Brazil, and identify factors linked to HCV infection.
- A total of 422 prisoners participated, with 3.1% testing positive for HCV antibodies; among those, 90.9% had genotype 1, and the highest risk factor was identified as injecting drug use.
- Key associations with HCV infection included age over 30, history of syphilis, and having household contact with an HCV positive individual, indicating that virus transmission occurs through parenteral exposure, sex, and close contact.
Article Synopsis
- Chronotropic incompetence (CI) is linked to increased mortality risk and coronary artery disease, yet its underlying mechanisms are unclear.
- A study analyzed 610 patients undergoing exercise echocardiography, dividing them into two groups based on their heart rate response during the test: those with CI (Chl) and those without (ChC).
- Findings revealed that patients with CI exhibited more symptoms like dyspnoea and hypertension, poorer exercise tolerance, and significant left ventricle dysfunction, particularly related to severe right coronary artery blockages.