Publications by Nathalie Lecomte

Publications by authors named "Nathalie Lecomte"

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Implication of Heterozygous Variants in Genes of the Leptin-Melanocortin Pathway in Severe Obesity.

Sophie Courbage Christine Poitou Johanne Le Beyec-Le Bihan Alexandra Karsenty Julie Lemale Nathalie Lecomte

J Clin Endocrinol Metab

September 2021

Article Synopsis

The study investigates the role of heterozygous variants in genes related to severe obesity, specifically focusing on LEP, LEPR, POMC, and PCSK1.
It analyzed data from 1486 individuals with severe obesity, finding a higher frequency of heterozygous variants compared to homozygous ones, and noted differences in BMI and obesity onset between these groups.
The findings suggest that heterozygous variants can lead to significant obesity-related phenotypes and highlight the need for targeted genetic analysis in cases of severe early-onset obesity for potential therapeutic strategies.

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An European pupil project linked to the scientific aims of the experiment AQUARIUS-XENOPUS on the taxi Soyuz flight Andromede to ISS.

Christian Dournon Herve Membre Pierre-Eric Brohm Aurore Coince Nathalie Cornu Nathalie Lecomte

J Gravit Physiol

July 2002

The German-French biological experiment AQUARIUS-XENOPUS which flew on the Soyuz flight Andromede to the International Space Station ISS (launched October 21, 2001 in Baikonour/Kazakhstan) was extended by an outreach project. Pupils of class 10 to 12 from Ulm/D and Nancy-Tomblaine/F studied swimming behavior of Xenopus tadpoles on ground. They were instructed to perform all experimental steps following the protocol of similar video recordings on ISS.

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