Publications by authors named "Nathalie Le Fur"
Aims: We investigated the effect of gadopiclenol, a new gadolinium-based contrast agent, on the QTc interval at clinical and supraclinical dose, considering the relative hyperosmolarity of this product.
Methods: This was a single centre, randomized, double-blind, placebo- and positive-controlled, 4-way crossover study. Forty-eight healthy male and female subjects were included to receive single intravenous (i.
Article Synopsis
- A multicenter phase III trial was conducted to compare the effectiveness and safety of combining pegylated liposomal doxorubicin (PLD) with carboplatin (CD) versus the standard carboplatin and paclitaxel (CP) for treating recurrent ovarian cancer in patients sensitive to platinum.
- The study involved 976 participants and found that the CD treatment led to significantly longer progression-free survival (PFS) of 11.3 months compared to 9.4 months for CP, with a lower hazard ratio indicating better outcomes in the CD group.
- While overall survival data is still being analyzed, the trial noted higher rates of severe toxicities and treatment discontinuation in the CP group, suggesting that CD offers