Publications by authors named "Nathalie Laplace"
Article Synopsis
- The study aimed to evaluate how operating room (OR) teams perceive risks and adopt safety measures when conducting hyperthermic intraperitoneal chemotherapy (HIPEC) and pressurized intraperitoneal aerosol chemotherapy (PIPAC).
- Conducted among OR teams from ten high-volume centers across six countries, the survey collected responses from various professionals, revealing that individual protection measure uptake was low at 51.4%.
- While PIPAC had a higher perceived protection level, all groups, particularly cleaning staff and anesthesiologists, showed a desire for more information, highlighting the need for better training on safety protocols in these procedures.
Background: A surgical peritoneal cancer index of >20 is often used to exclude patients from cytoreductive surgery for colorectal peritoneal metastases. The pathologic peritoneal cancer index in these patients may be <20.
Objective: The purpose of this study was to compare the pathologic and surgical findings and to look at potential pathologic prognostic factors.
Background: PIPAC is a recent approach with promising results for patients with peritoneal metastasis (PM). We aimed to evaluate survival and postoperative outcome of patients with unresectable PM from gastric origin treated with chemotherapy and PIPAC.
Methods: A retrospective analysis of a prospective maintained PIPAC database was queried for all patients diagnosed with unresectable PM from gastric cancer who underwent PIPAC before 2018.
Aims: The peritoneal regression grading score (PRGS) and peritoneal cytology (PC) assess response to chemotherapy in peritoneal metastasis (PM) in a setting of palliative treatment by pressurized intraperitoneal aerosol chemotherapy (PIPAC). Progression has been defined as an increase of PRGS between first and third PIPAC procedures (iPRGS). iPRGSand positive peritoneal cytology were not associated with prognostic impact.
View Article and Find Full Text PDFPressurised intraperitoneal aerosol chemotherapy (PIPAC) was introduced as a new treatment for patients with peritoneal metastases in November, 2011. Reports of its feasibility, tolerance, and efficacy have encouraged centres worldwide to adopt PIPAC as a novel drug delivery technique. In this Review, we detail the technique and rationale of PIPAC and critically assess its evidence and potential indications.
View Article and Find Full Text PDFBackground: PIPAC is a recent method of intraperitoneal chemotherapy. The aim of this study was to describe the clinical characteristics of the patients who became amenable to CRS & HIPEC after PIPAC treatment.
Methods: All patients diagnosed with unresectable PM who became resectable throughout PIPAC treatment were included.
Introduction: Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a promising technic for unresectable peritoneal metastasis (PM). Targeted therapies such as bevacizumab have demonstrated their efficacy in advanced colorectal and ovarian cancer. We aimed to evaluate the feasibility and safety of this bidimensional therapeutic association.
View Article and Find Full Text PDFObjective: To determine the validity of hospital administrative databases compared to prospective collection of medical data assessing thyroid surgery complications.
Background: Administrative data are increasingly used to track surgical outcomes.
Methods: All patients undergoing thyroid surgery at three French university hospitals between April 2008 and April 2009 were prospectively included.
In the original article, Mathieu Bonal's last name was spelled incorrectly. It is correct as reflected here. The original article has also been updated.
View Article and Find Full Text PDFArticle Synopsis
- Total thyroidectomy for Graves' disease can increase hemorrhage risk due to hypervascularization of the thyroid, complicating the identification of critical nearby structures during surgery.
- A study at a single center from November 2010 to November 2015 reviewed outcomes of 380 patients who underwent this procedure without preoperative treatment using Lugol's solution.
- The results showed no deaths, with rates of recurrent laryngeal nerve palsy at 7.89% and permanent hypoparathyroidism at 3.68%, suggesting that iodine pretreatment may not be necessary, although further research is needed.
Background: Adrenocortical carcinoma is a rare neoplasm with a high rate of recurrence. We studied the impact of surgery on the survival in recurrent adrenocortical carcinoma patients.
Methods: We performed a retrospective review of patients with recurrent adrenocortical carcinoma, managed in 5 French University Hospitals between 1980 and 2014.
Sympathetic nervous system (SNS) plays a key role in cardiac homeostasis and its deregulations always associate with bad clinical outcomes. To date, little is known about molecular mechanisms regulating cardiac sympathetic innervation. The aim of the study was to determine the role of fibroblasts in heart sympathetic innervation.
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