Publications by authors named "Nathalie J Rodrigues Simoes"
Splenic biopsies for cytology remain challenging due to the inherent difficulty in obtaining adequate samples and the paucity of literature on rare entities arising in the spleen. Among these, are tumors arising from blood vessels, lymphomas and rarely, mesenchymal dendritic cell neoplasms. An important but rarely considered entity primarily arising in the spleen is Epstein-Barr virus-positive inflammatory follicular dendritic cell sarcoma (EBV+ IFDCS).
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- - Recently identified mesenchymal tumors with GLI1 fusions or amplifications have been recognized as a unique group, needing clearer classification and criteria.
- - A study of 16 adult cases revealed various primary sites, mostly in soft tissue, and characterized histologically by uniform cell patterns with distinct features, including lymphovascular invasion in some instances.
- - These tumors exhibit specific genetic alterations linked to GLI1, and findings suggest a potentially aggressive nature, with half of those monitored showing distant metastases, highlighting the need for further investigation and understanding of their behavior.