Novel severe wheezy young children phenotypes: boys atopic multiple-trigger and girls nonatopic uncontrolled wheeze.

Background: Recurrent wheezing during infancy is a heterogeneous disorder that has been associated with early-onset asthma.

Objective: To identify phenotypes of severe recurrent wheezing and therapeutic approaches.

Methods: We performed cluster analysis with 20 variables of 551 children with active asthma, younger than 36 months old, and enrolled in the Trousseau Asthma Program.