Publications by authors named "Nathalie Gouge-Biebuyck"
Article Synopsis
- Long-term multilineage hematopoietic donor chimerism is a rare occurrence in patients receiving solid organ transplants, particularly those from lymphoid-rich organs like the intestine or liver.
- Unlike other organs, there has been no evidence of kidney-resident hematopoietic stem cells in mammals, but new findings suggest they may exist.
- A case study of a pediatric kidney transplant recipient indicates that these kidney-derived stem cells can reside in bone marrow long-term, ultimately replacing the host's stem cells and achieving full donor chimerism in blood lineages.
Acute graft-versus-host disease (GVHD) is a rare but frequently lethal complication after solid organ transplantation. GVHD occurs in unduly immunocompromised hosts but requires the escalation of immunosuppression, which does not discriminate between host and donor cells. In contrast, donor-targeted therapy would ideally mitigate graft-versus-host reactivity while sparing recipient immune functions.
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