Patient considerations in the management of multiple sclerosis: development and clinical utility of oral agents.

Multiple sclerosis (MS) is one of the most frequently occurring disabling neurological disorders among young adults in Canada. It is a chronic inflammatory disorder of the central nervous system (CNS) that is thought to be immune mediated in nature. An estimated 55,000-75,000 Canadians suffer from this debilitating disease.

Management strategies for improving the tolerability of interferons in the treatment of multiple sclerosis.

Interferon beta therapies for multiple sclerosis (MS) are well tolerated during long-term use, but the first year of treatment is a critical risk period for nonadherence and discontinuation. Some of the most common reasons for discontinuation include adverse effects (including flu-like symptoms and injection site reactions). Minimizing the impact of adverse effects is crucial in helping patients adhere to their treatment regimens, and improving their chances of better health over the longer term.