Publications by authors named "Nathalie Caversaccio"
Background: Recurrent infections of the nose, sinuses and ears are common problems for people with primary ciliary dyskinesia. While pulmonary exacerbations in primary ciliary dyskinesia are defined, there is no definition for ear-nose-throat exacerbations, a potential outcome for research and clinical trials.
Methods: We set up an expert panel of 24 ear-nose-throat specialists, respiratory physicians, other healthcare professionals and patients to develop consensus definitions of sinonasal and otological exacerbations in children and adults with primary ciliary dyskinesia for research settings.
Lack of Correlation of Sinonasal and Otologic Reported Symptoms With Objective Measurements Among Patients With Primary Ciliary Dyskinesia: An International Study.
Clin Exp Otorhinolaryngol
November 2023
Characteristics of Otologic Disease Among Patients With Primary Ciliary Dyskinesia.
JAMA Otolaryngol Head Neck Surg
July 2023
Article Synopsis
- Otologic disease is prevalent among individuals with primary ciliary dyskinesia (PCD), but detailed information regarding its severity and characteristics is limited.
- A study analyzed data from 397 participants across 12 specialized centers to assess the prevalence of ear-related symptoms and findings, revealing significant ear pain, discharge, and hearing issues, particularly in adults.
- Key findings included a high prevalence of otitis media with effusion, frequent reports of hearing impairment, and identifying autumn as a major risk factor for increased ear inflammation.
Objectives: In patients with chronic liver diseases, hypercoagulability can contribute to the progression of fibrosis and complications of cirrhosis. Tissue factor (TF) is a transmembrane glycoprotein that initiates the extrinsic pathway of blood coagulation. Recent investigations have established that TF is elevated in patients with pancreatic cancer, blood disorders, diabetes, and cardiovascular disease.
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