Relationship between Abdominal Pressure, Pulmonary Compliance, and Cardiac Preload in a Porcine Model.

Rationale. Elevated intra-abdominal pressure (IAP) may compromise respiratory and cardiovascular function by abdomino-thoracic pressure transmission. We aimed (1) to study the effects of elevated IAP on pleural pressure, (2) to understand the implications for lung and chest wall compliances and (3) to determine whether volumetric filling parameters may be more accurate than classical pressure-based filling pressures for preload assessment in the setting of elevated IAP.

Pathophysiology of renal hemodynamics and renal cortical microcirculation in a porcine model of elevated intra-abdominal pressure.

Background: Elevated intra-abdominal pressure (IAP) has been shown to impair renal perfusion and renal function. This study was designed to further investigate the effects of elevated IAP on renal venous hemodynamics and renal perfusion pressure (RPP). Another aim was to evaluate the renal cortical microcirculation by sidestream dark field (SDF) imaging in a porcine model of elevated IAP.