Publications by authors named "Nathalie Boutry"

Objective: To demonstrate the usefulness of ultrasonography in detecting knee ossification centers in infants with permanent congenital hypothyroidism (PCH).

Methods: From 2011 to 2021, all infants with PCH referred for thyroid ultrasound also underwent left knee ultrasound and radiography on the same day. Knee radiographs were compared with knee sonograms.

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  • The article discusses two fetal cases of gnathodiaphyseal dysplasia (GDD), a rare genetic disorder characterized by bone bowing and jaw lesions.
  • Genetic tests confirmed the diagnosis by identifying new variants in the ANO5 gene.
  • The review emphasizes the importance of recognizing GDD for better diagnosis and management of the condition in healthcare settings.
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Background: In the presence of pain over the lateral aspect of the foot or recurrent ankle sprain in children, medical imaging is often employed to investigate potential causes, such as a calcaneonavicular coalition or a too-long anterior process (TLAP) of the calcaneus. Diagnosis and categorization of calcaneonavicular coalitions (synostosis, synchondrosis, or synfibrosis) is generally facilitated through imaging, in contrast to TLAP, which lacks well-defined semiological characteristics, apart from a calcaneonavicular space measurement of less than 5 mm. However, this measurement initially performed on an oblique view radiograph can be subject to a lack of precision due to positional variations of the foot and overlapping bones.

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We discuss several variants of the metaphyseal and diaphyseal bone surfaces that may be misleading in clinical practice. They include metaphyseal stripes, spiculated metaphyseal cortex, cortical desmoid, laminated lateral supracondylar ridge, cortical vascular canals, variations in shape or lucency of normal tuberosities, cortical thickening of normal ridges, and well-organized undulated hyperostosis at the proximal phalanges.

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Introduction: The COVID-19 pandemic was a stressful period. Lockdowns may have added to parental difficulty leading to an increase in violence. This study aimed to compare the monthly incidence of high suspicion of child physical abuse before and during the COVID-19 pandemic.

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Introduction: Although the association between Too-Long Anterior Calcaneal Process (TLACP) and osteochondral lesion of the dome of the talus (OCL) has been hypothesized, no study has investigated the interrelations between TLACP, hind and mid-tarsal volumes and angles and the development of OCL. The main goals of this work are: (1) to measure the volume of the calcaneum, talus, navicular and cuboid in subjects with and without TLACP; (2) to evaluate the angular relationships between talus, calcaneum and navicular in subjects with and without TLACP; (3) to assess whether TLACP has an effect on the volume of OCL.

Methods: This is a retrospective study of 69 CT scans of 54 consecutive children aged 11-15 years who had undergone a CT scan due to symptomatology suggestive of TLACP.

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Introduction: The too-long anterior process (TLAP) increases mechanical stress on the hindfoot and could lead to osteochondral lesions of the talus (OLT) by localized hyper-pressure. The purpose of this study is to investigate an association between TLAP and OLT in children.

Methods: This is a retrospective, multicenter, case-control study conducted between 2010 and 2020.

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Article Synopsis
  • The study analyzes the morpho-anatomical traits of excessively long anterior calcaneal processes in patients with ankle pain and recurrent sprains, utilizing CT scans of 69 feet.
  • A significant 71% of the examined feet displayed pathological features, particularly a reduced calcaneo-navicular distance and other distinct measurement anomalies compared to normal feet.
  • Four morphotypes of the too-long anterior calcaneal process were classified based on anatomical shape: absence, triangular, rectangular, and coalition, highlighting the process's complex 3D structure.
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PIK3CA-related overgrowth spectrum (PROS) includes rare genetic conditions due to gain-of-function mutations in the PIK3CA gene. There is no approved medical therapy for patients with PROS, and alpelisib, an approved PIK3CA inhibitor in oncology, showed promising results in preclinical models and in patients. Here, we report for the first time the outcome of two infants with PROS having life-threatening conditions treated with alpelisib (25 mg) and monitored with pharmacokinetics.

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  • Identifying congenital skeletal abnormalities is challenging due to the wide range of syndromes and dysplasias, requiring a mix of clinical, radiologic, and genetic tests for accurate diagnosis.
  • Imaging, particularly of the hand and wrist, is crucial for determining which patients need genetic counseling and testing, as it can provide valuable insights into various skeletal conditions.
  • The article outlines a systematic approach for analyzing hand and wrist radiographs to help identify congenital and developmental diseases and emphasizes the correct use of terminology while discussing specific examples of skeletal dysplasias.
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  • This study analyzed lung CT findings in children with pulmonary Langerhans cell histiocytosis (PLCH) to assess previously established scoring systems used for adults.
  • Out of 175 children with PLCH, 60 were selected for review, revealing that at diagnosis, many of the children had nodules (63%) and cysts (53%), with an increase in both findings as the disease progressed.
  • The research concluded that the characteristics of PLCH in children mirror those in adults, and the adult CT scoring systems could be effectively utilized for pediatric cases, noting that lesions often occur at the costophrenic angles and that alveolar consolidation is potentially atypical in this age group.
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Normal bone growth of the pediatric knee as well as normal variants of ossification result in different appearances that can be identified on imaging (radiography/MR imaging). Familiarity with these changes is important to avoid confusing normal growth with pathology. This article illustrates the main features related to normal bone growth (growth arrest lines, physeal changes, ossification centers within the epiphysis, hematopoietic marrow within the metaphysis) and physis disappearance (« FOPE »).

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We discuss the imaging of several juvenile inflammatory arthropathies including juvenile idiopathic arthritis, juvenile systemic lupus erythematosus, juvenile scleroderma, juvenile dermatomyositis, and chronic recurrent multifocal osteomyelitis. Juvenile idiopathic arthritis is the most common autoimmune chronic systemic disease of connective tissue in children. The remaining systemic juvenile connective tissue diseases are rare.

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  • The study investigates the efficacy of a microdose radiography protocol compared to a low-dose protocol for measuring lower limb alignment in children aged 6 and older.
  • Results showed that microdose provided high agreement in measurements among observers and significantly reduced radiation exposure, achieving dose reductions of up to 8.5 times.
  • The findings suggest that microdose biplanar radiography is a viable option for evaluating lower limb lengths and deviations in children, with a substantial decrease in radiation doses.
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Objective: To describe a new sonographic feature for a traumatic lesion of the ankle in children.

Materials And Methods: We present a retrospective review of superior extensor retinaculum (SER) avulsions diagnosed by ultrasound (US) as a cause of subperiosteal haematoma (SPH) and periosteal apposition of the distal fibula in seven children (3 girls and 4 boys, mean age 13.4 years; age range 10-15 years) after an inversion trauma of the ankle.

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Objective: To evaluate prospectively the performance of diffusion-weighted imaging (DWI) for the detection of active lesions on MR enterography (MRE) in children with inflammatory bowel disease (IBD).

Methods: MRE of 48 children (mean age 13 years) with suspected or known IBD were blindly analysed by 2 independent readers for the presence of active lesions. Two sets of imaging including DWI and gadolinium-enhanced imaging (GEI) were reviewed.

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This article presents the recommendations of the European Society of Musculoskeletal Radiology Arthritis Subcommittee regarding the standards of the use of MRI in the diagnosis of musculoskeletal rheumatic diseases. The recommendations discuss (1) the role of MRI in current classification criteria of musculoskeletal rheumatic diseases (including early diagnosis of inflammation, disease follow-up, and identification of disease complications); (2) the impact of MRI on the diagnosis of axial and peripheral spondyloarthritis, rheumatoid arthritis, and juvenile spondyloarthritis; (3) MRI protocols for the axial and peripheral joints; (4) MRI interpretation and reporting for axial and peripheral joints; and finally, (5) methods for assessing MR images including quantitative, semiquantitative, and dynamic contrast-enhanced MRI studies.

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Constitutive COL2A1 mutations are associated with a wide variety of clinical manifestations known as type II collagenopathies. Among them is Kniest dysplasia, which is phenotypically variable and includes both skeletal (short trunk and limbs, kyphoscoliosis, prominent joints, and osteoarthritis) and craniofacial characteristics. Kniest dysplasia mutations primarily arise in the triple-helicoidal region of the alpha 1 (II) chain in COL2A1 between exons 12 and 24.

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  • Tuberous sclerosis complex (TSC) often affects the kidneys, leading to lesions such as angiomyolipomas (AML) and cysts, and can co-occur with autosomal dominant polycystic kidney disease (ADPKD), creating a contiguous gene syndrome (CGS).
  • The study reviewed ultrasound findings of 55 children with TSC or CGS, analyzing lesion types, sizes, and their progression over time.
  • The results indicated that lesions can be categorized into four groups, with specific ultrasound features suggesting either classical TSC or CGS, while showing that angiomyolipoma growth accelerates significantly after age 12, and complications from these conditions are rare.
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  • Idiopathic scoliosis is a common spinal deformity in children that is usually evaluated using traditional X-rays, which may require multiple exposures.
  • A new biplanar X-ray device allows for frontal and lateral images at lower radiation doses while assessing spinal deformities.
  • This advanced imaging technique produces 3D images of the spine, improving visualization and assessment of idiopathic scoliosis in all three planes.
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Background: The incidence of childhood bone and joint infections (BJIs) is not well known, but is useful for identifying epidemiological differences and improving practice.

Objective: To determine the incidence of BJI in previously well children and describe their clinical, laboratory and radiological characteristics.

Design: A multicentre, population-based, prospective study performed from July 2008 through June 2009.

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This article reflects the radiologist's perspective on the imaging and interpretation of axial spondylarthritis (SpA). The arthritis subcommittee of the European Society of Skeletal Radiology provides a consensus for the following questions: When and how should we image? How should we analyze the images? How should we interpret the imaging findings? To answer these questions, we address the indications in imaging axial SpA and the different imaging techniques, with a special focus on magnetic resonance imaging protocols. The value of different imaging modalities is discussed.

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Unlabelled: Langerhans cell histiocytosis (LCH) represents a disorder characterised by an abnormal accumulation of histiocytes in miscellaneous tissues. The bone is commonly affected, especially the flat bones, the spine and the long bones. Some lesions in children such as a "vertebra plana" or a solitary lytic lesion of the skull may be suggestive for LCH, whereas others can be confused with a malignant tumour or osteomyelitis.

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  • Osteogenesis imperfecta (OI) is a genetic disorder that results in fragile bones and is characterized by varying severity, ranging from mild to life-threatening, often linked to abnormalities in type I collagen.
  • While severe cases are typically diagnosed before birth, milder cases can be challenging to identify and may be misinterpreted as child abuse, with conventional radiography being essential for diagnosis.
  • Recent advancements, particularly biphosphonate therapy, have improved the prognosis for OI, and this review aims to highlight the radiographic signs of OI to help differentiate it from non-accidental injury.
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