Resurgence of , including one macrolide-resistant isolate, France, 2024.

As other European countries, France is experiencing a resurgence of pertussis in 2024. Between 1 January and 31 May 2024, 5,616 (24.9%) positive qPCR tests were identified, following a 3-year period of almost null incidence.

Transient reemergence of in France in 2022.

Between March and October 2022, a peak of detection of by qPCR, real-time PCR was observed in France. Whether this peak was due to resurgence from previous circulating lineages or reintroduction into the country was unknown. The objective of this study is to understand transient increase observed in France in 2022 whereas it had virtually stopped being reported since the start of the COVID-19 pandemic in 2020.

Corynebacterium ramonii sp. nov., a novel toxigenic member of the Corynebacterium diphtheriae species complex.

The Corynebacterium diphtheriae species complex comprises seven bacterial species, including Corynebacterium ulcerans, a zoonotic pathogen from multiple animal species. In this work, we characterise phenotypically and genotypically isolates belonging to two C. ulcerans lineages.

A comprehensive resource for Bordetella genomic epidemiology and biodiversity studies.

The genus Bordetella includes bacteria that are found in the environment and/or associated with humans and other animals. A few closely related species, including Bordetella pertussis, are human pathogens that cause diseases such as whooping cough. Here, we present a large database of Bordetella isolates and genomes and develop genotyping systems for the genus and for the B.

Global spatial dynamics and vaccine-induced fitness changes of .

As with other pathogens, competitive interactions between strains drive infection risk. Vaccines are thought to perturb strain diversity through shifts in immune pressures; however, this has rarely been measured because of inadequate data and analytical tools. We used 3344 sequences from 23 countries to show that, on average, there are 28.

Evolution of over a 23-year period in France, 1996 to 2018.

Background is the main agent of whooping cough. Vaccination with acellular pertussis vaccines has been largely implemented in high-income countries. These vaccines contain 1 to 5 antigens: pertussis toxin (PT), filamentous haemagglutinin (FHA), pertactin (PRN) and/or fimbrial proteins (FIM2 and FIM3).

Low Detection Rate of Using the BioFire FilmArray Respiratory Panel 2.

Syndromic respiratory panels are increasingly used worldwide. Their performance for detection of needs to be evaluated. We found that the FilmArray Respiratory Panel 2 (RP2+) assay, which uses the pertussis toxin promoter target for , can only detect highly charged samples.