Antileukotriene reverts the early effects of inflammatory response of distal parenchyma in experimental chronic allergic inflammation.

Aims: Compare the effects of montelukast or dexamethasone in distal lung parenchyma and airway walls of guinea pigs (GP) with chronic allergic inflammation.

Methods: GP have inhaled ovalbumin (OVA group-2x/week/4weeks). After the 4th inhalation, GP were treated with montelukast or dexamethasone.

Effects of corticosteroid, montelukast and iNOS inhibition on distal lung with chronic inflammation.

Unlabelled: We evaluated the effects of anti-iNOS (1400W - W) associated with leukotriene antagonist (montelukast - M) or corticosteroid (dexamethasone - D) on distal lung of guinea pigs (GP) with chronic pulmonary inflammation.

Methods: GP were inhaled with ovalbumin (OVA-2×/week/4 weeks), treated with M (OVAM), D (OVAD) and/or W (OVAW, OVADW, OVAMW) and distal lungs were evaluated by morphometry.

Results: Isolated treatments were not sufficient to reduce all parameters.