Publications by authors named "Nathalia Beatriz Ramos de Sa"
The impact of early anti-SARS-CoV-2 antibody production on the length of hospitalization stay among COVID-19 patients.
Microbiol Spectr
December 2023
The study provides valuable insights into the sociodemographic characteristics, clinical outcomes, and humoral immune response of those affected by the virus that has devastated every field of human life since 2019; the COVID-19 patients. Firstly, the association among clinical manifestations, comorbidities, and the production of neutralizing antibodies (Nabs) against SARS-CoV-2 is explored. Secondly, varying levels of Nabs among patients are revealed, and a significant correlation between the presence of Nabs and a shorter duration of hospitalization is identified, which highlights the potential role of Nabs in predicting clinical outcomes.
View Article and Find Full Text PDFInflammasome genes polymorphisms are associated with progression to mechanical ventilation and death in a cohort of hospitalized COVID-19 patients in a reference hospital in Rio de Janeiro, Brazil.
Gene
May 2023
Article Synopsis
- The study investigated how specific genetic variations (SNPs) in inflammasome genes affect the severity of COVID-19, particularly leading to mechanical ventilation or death, by analyzing 451 hospitalized patients in Brazil.
- Certain alleles like G in NLRP3 rs10754558 were linked to slower disease progression, while other variations, such as the C allele in NLRP3 rs4612666, were associated with faster progression to death.
- Findings suggest that genetic differences in inflammasome-related genes could play a role in determining the critical outcomes of COVID-19, indicating a potential area for future research and intervention strategies.
Inflammasome genetic variants are associated with tuberculosis, HIV-1 infection, and TB/HIV-immune reconstitution inflammatory syndrome outcomes.
Front Cell Infect Microbiol
October 2022
Article Synopsis
- The study investigates how specific genetic variations (SNPs) and inflammatory cytokine levels are linked to tuberculosis (TB) and HIV, focusing on TB-HIV co-infection and the onset of immune reconstitution inflammatory syndrome (IRIS).
- Results indicate that certain SNPs in the NLRP3 and IL-1β genes influence the risk of developing extrapulmonary TB and the onset of TB in HIV-infected individuals, with varying risks associated with different genetic profiles.
- Elevated levels of cytokines IL-6 and IL-33 were noted in TB patients, while low CD8 cell counts and the presence of extrapulmonary TB were significant risk factors for IRIS onset.
Inflammasome Genetic Variants Are Associated with Protection to Clinical Severity of COVID-19 among Patients from Rio de Janeiro, Brazil.
Biomed Res Int
September 2022
COVID-19 has a broad spectrum of clinical manifestations, from asymptomatic or mild/moderate symptoms to severe symptoms and death. The mechanisms underlying its clinical evolution are still unclear. Upon SARS-CoV-2 infection, host factors, such as the inflammasome system, are activated by the presence of the virus inside host cells.
View Article and Find Full Text PDFBackground: Tuberculosis (TB) and AIDS are the leading causes of infectious disease death worldwide. In some TB-HIV co-infected individuals treated for both diseases simultaneously, a pathological inflammatory reaction termed immune reconstitution inflammatory syndrome (IRIS) may occur. The risk factors for IRIS are not fully defined.
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