Publications by authors named "Nate Price"
Article Synopsis
- - The study investigates how cholinergic innervation affects cerebral blood flow in relation to Alzheimer's disease (AD), finding that young 3xTgAD mice show a stronger response to acetylcholine than wild-type, but this response diminishes with age in the 3xTgAD group.
- - There is evidence of reduced choline acetyltransferase protein levels in the neocortex of 3xTgAD mice, which suggests a cholinergic deficit, yet young 3xTgAD mice still maintain cerebrovascular reactivity to acetylcholine.
- - The research highlights the presence of tau pathology and microglial changes in the basal forebrain of 3xTgAD mice
RNA viruses continue to remain a threat for potential pandemics due to their rapid evolution. Potentiating host antiviral pathways to prevent or limit viral infections is a promising strategy. Thus, by testing a library of innate immune agonists targeting pathogen recognition receptors, we observe that Toll-like receptor 3 (TLR3), stimulator of interferon genes (STING), TLR8, and Dectin-1 ligands inhibit arboviruses, Chikungunya virus (CHIKV), West Nile virus, and Zika virus to varying degrees.
View Article and Find Full Text PDFRNA viruses continue to remain a clear and present threat for potential pandemics due to their rapid evolution. To mitigate their impact, we urgently require antiviral agents that can inhibit multiple families of disease-causing viruses, such as arthropod-borne and respiratory pathogens. Potentiating host antiviral pathways can prevent or limit viral infections before escalating into a major outbreak.
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