Lipid peroxidation and antioxidant enzyme activities in erythrocytes of type 2 diabetic patients.

Background And Objective: Although diabetes mellitus (DM) patients are claimed to be under oxidative stress because of prolonged exposure to hyperglycemia, the influence of glycemic control and cardiovascular complication in diabetes on oxidative stress parameters has not been fully studied. The present study aimed to investigate lipid peroxidation end product (malondialdehyde, MDA) and antioxidant enzymes in fairly controlled type 2 DM (fasting plasma glucose [FPG] < or = 180 mg/dl) or type 2 DM complicated with coronary heart disease (CHD) and poorly controlled type 2 DM (FPG > 180 mg/dl) in comparison to a normal healthy group (FPG < 110 mg/dl).

Material And Method: MDA and antioxidant enzymes such as superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) were determined in the red cell of 19 subjects with poorly controlled type 2 DM, 26 subjects with fairly controlled type 2 DM and 20 subjects with type 2 DM complicated with CHD who were matched for age and gender.

Glutathione and glutathione peroxidase in type 1 diabetic patients.

Objective: Diabetic (DM) patients are claimed to be under oxidative stress because of hyperglycemia. The influence of free radical production by this hyperglycemic induction may involve cardiovascular complications in diabetes. The present study aimed to compare the glutathione (GSH) level and glutathione peroxidase (GPx) activity in type 1 DM and a normal healthy group.

Plasma lipid peroxidation and antioxidiant nutrients in type 2 diabetic patients.

Background And Objective: Observation shows diabetic patients to be more prone to oxidative stress because of hyperglycemia. The elevation of free radical production by this hyperglycemic production may exacerbate cardiovascular complication in diabetes. This study aims to investigate the oxidative stress related parameters in type 2 DM.

Antioxidant status and lipid peroxidation end products in patients of type 1 diabetes mellitus.

Background And Objective: In Type 1 diabetes mellitus (DM), hyperglycemia is considered a primary cause of diabetic vascular complications and is associated with oxidative stress. The role of antioxidants, particularly alpha tocopherol, in Type 1 DM and its contribution in the development of vascular complications is not clear. Therefore, the present study aims to investigate the relationship between antioxidant status (alpha tocopherol) and lipid peroxidation end products (malondialdehyde; MDA) in the plasma of 20 Type 1 DM and 20 nondiabetic healthy control subjects.