A 2H-tetrahydropyran derivative and bioactive constituents from the bark of Goniothalamus elegants Ast.

A new 2H-tetrahydropyran derivative, 6-epi-goniothalesdiol A (1), together with nine known styryllactones (2-10) and five known aristolactams (11-15) were isolated from the bark of Goniothalamus elegants Ast. The structures were elucidated by spectroscopic methods. The isolated compounds were evaluated for their cytotoxicity toward the KB, MCF7 and NCI-H187 cell lines as well as antimalarial and antimycobacterial activities.

Radical scavenging activities of flavonoids from roots of Akschindlium godefroyanum.

Chemical constituents of crude ethyl acetate extract of roots of Akschindlium godefroyanum (Kuntze) H. Ohashi were investigated and seven flavonoids were isolated. Their structures were identified based on spectroscopic methods as well as by comparison with spectral data reported in the literature as six flavanonols and a flavonol including 7,4'-dihydroxy-5,3'-dimethoxyflavanonol (1), neophellamuretin (2), taxifolin (3), erycibenin D (4), geraldol (5), fustin (6) and garbanzol (7).

Chemical constituents from the fungus Chaetomium cupreum RY202.

Two new angular types of azaphilones, isochromophilonol (1) and ochrephilonol (2), together with ten known compounds (3-12), were isolated from Chaetomium cupreum RY202. Their structures were established on the basis of spectroscopic data and the absolute configurations of 1 and 3 were determined by the modified Mosher's method. Compounds 1, 2 and 4 showed moderated cytotoxicity against KB and NCI-H187 cell lines (IC50 9.

Cytotoxic and antimalarial azaphilones from Chaetomium longirostre.

Four new azaphilones named longirostrerones A-D (1-4) and three known sterols, ergosteryl palmitate, ergosterol, and ergosterol peroxide, have been isolated from ethyl acetate extract of the fungus Chaetomium longirostre. These structures were determined by 1D and 2D NMR, IR, UV, MS, and CD spectroscopy. Compounds 1-4 exhibited strong cytotoxicity against KB cancer cell lines (IC(50) 0.

Polyacetylenes from the roots of Polyalthia debilis.

Six new linear polyacetylenic C25 and C27 acetogenins (1-6), named debilisones A-F, have been isolated from a methanol extract of roots of Polyalthia debilis. Structures of these compounds were determined by spectroscopic techniques. The absolute configuration at C-17 of 2 was assigned by the modified Mosher's method.

Galloyl and hexahydroxydiphenoyl esters of phenylpropanoid glucosides, phenylpropanoids and phenylpropanoid glucosides from rhizome of Balanophora fungosa.

Five new galloyl and (S)-hexahydroxydiphenyl (HHDP) esters of phenylpropanoid glucosides; 1-O-(E)-coumaroyl-3-galloyl-4,6-(S)-HHDP-beta-D-glucopyranose (21), 1-O-(E)-coumaroyl-3,4,6-trigalloyl-beta-D-glucopyranose (22), 1-O-(E)-caffeoyl-3,4,6-trigalloyl-beta-D-glucopyranose (23), 1-O-(E)-cinnamoyl-3-galloyl-4,6-(S)-HHDP-beta-D-glucopyranose (24), and 1-O-(E)-cinnamoyl-4-galloyl-beta-D-glucopyranose (25), together with twenty known compounds which were identified as four triterpenes (1, 2, 3, 5), one steroid (4), one lignan (6), three phenylpropanoids (7, 8, 14), five phenylpropanoid glucosides (10, 12, 13, 15, 16), five galloyl and HHDP esters of phenylpropanoid glucosides (11, 17-20), and one bischroman (9). Their structures were determined on the basis of 1D and 2D spectroscopic data.