Influence of and polymorphisms on spontaneous preterm birth in North East Brazil: genetics and preterm birth.

The mannose-binding lectin () and nitric oxide synthase 3 () genes are associated with the immune response against inflammatory processes, have been reported as possibly related with premature birth. Until now, most of the researches regarding the genetic influence of prematurity have revealed limited results because only investigating the child or the mothers' genotypes, thus not exploring the possible effects of interactions between these genotypes or the interactions with environmental factors related to the duration of pregnancy. We performed a replica study investigating the influence of single nucleotide polymorphisms (SNPs) in and genes on premature birth, also considering socioeconomic, demographic, and gestational factors.