Topical application of a P2X2/P2X3 purine receptor inhibitor suppresses the bitter taste of medicines and other taste qualities.

Background And Purpose: Many medications taste intensely bitter. The innate aversion to bitterness affects medical compliance, especially in children. There is a clear need to develop bitter blockers to suppress the bitterness of vital medications.

Inhibition of Bitter Taste from Oral Tenofovir Alafenamide.

Children have difficulty swallowing capsules. Yet, when presented with liquid formulations, children often reject oral medications due to their intense bitterness. Presently, effective strategies to identify methods, reagents, and tools to block bitterness remain elusive.

Evaluating the effectiveness of the timing of postoperative education in the pediatric population.

The purpose of this pilot study was to evaluate the impact of timing for providing parents with postoperative education in the pediatric setting, their ability to retain information, and their satisfaction with the education provided. A total of 70 subjects were enrolled and randomly assigned to a control or intervention group. The control group received postoperative education just before discharge home, whereas the intervention group received the education during their child's surgical procedure.

Frozen Film and FOSDIC Forms: Restoring the 1960 U.S. Census of Population and Housing.

In this article, the authors describe a collaboration of the Minnesota Population Center (MPC), the U.S. Census Bureau, and the National Archives and Records Administration to restore the lost data from the 1960 Census.

Drosophila melanogaster prefers compounds perceived sweet by humans.

To understand the functional similarities of fly and mammalian taste receptors, we used a top-down approach that first established the fly sweetener-response profile. We employed the fruit fly Drosophila melanogaster, an omnivorous human commensal, and determined its sensitivity to an extended set of stimuli that humans find sweet. Flies were tested with all sweeteners in 2 assays that measured their taste reactivity (proboscis extension assay) and their ingestive preferences (free roaming ingestion choice test).