Comparison of polyhexamethylene biguanide and chlorhexidine as monotherapy agents in the treatment of Acanthamoeba keratitis.

Purpose: To compare the therapeutic outcomes of polyhexamethylene biguanide (PHMB) and chlorhexidine for Acanthamoeba keratitis.

Design: Prospective, double-masked, randomized comparative study.

Methods: Fifty-six eyes of 55 patients with Acanthamoeba keratitis were randomized to receiving PHMB 0.

Comparison of conventional and silicone hydrogel contact lenses for bullous keratoplasty.

Purpose: To compare the efficacy and safety of conventional lenses and silicone hydrogel lenses in the treatment of bullous keratopathy. The silicone hydrogel bandage contact lenses used were Focus NIGHT & DAY and PureVision. The conventional lens used was Sauflon 85%.

First genomic localization of oculo-oto-dental syndrome with linkage to chromosome 20q13.1.

Purpose: To characterize the phenotype of autosomal dominant oculo-oto-dental (OOD) syndrome, map the disease locus in a five-generation British family, and evaluate a candidate gene.

Methods: Full clinical assessments in all affected patients included slit lamp and retina examination, refraction, A-scan ultrasound, audiograms, and dental assessments. Genomic DNA from all family members was genotyped, by polymerase chain reaction, for polymorphic genetic markers covering the entire genome.