Development steps of multimodal exercise interventions for older adults with multimorbidity: A systematic review.

Background And Aims: Multicomponent exercise interventions are recommended for older adults and for those with chronic diseases. While multiple programs have been tested, no one has yet explored how these programs were developed. This review set out to determine what development steps multicomponent exercise intervention studies that include older adults with multimorbidity have taken.

Normal Outcome With Prenatal Intervention for Riboflavin Transporter Defect.

Background: Riboflavin transporter deficiency is a rare but severe neurometabolic disorder.

Methods: We report two siblings with pathogenic variants in SLC52A3 gene, resulting in riboflavin transporter 3 deficiency.

Results: The first sibling was diagnosed at age 11 months with severe respiratory compromise and regression of developmental milestones.